Review: Potential Effectiveness of Paleolithic Nutritional Interventions in Treatment of Gynecological Cancers

Background: Limited research has been performed for treating gynecological disease conditions using paleodiet intervention. It is in demand to conduct many randomized controlled trials to prove its effectiveness. This review indicates one of the most important literature gaps in gynae-oncology. Paleo nutrition has recently emerged as a treatment option in conditions related to gynecology, and such potential benefits are indicated in few short-term clinical trials and case reports related to gynecological cancers and malignancies. Objective: This meta-analysis is aimed to address the importance of nutritional intervention, with emphasis on paleo nutrition, in treatment of gynecological cancers, pre-malignancy conditions, and post-operative recovery in women. Materials: PubMed, Scopus, SciPubs, Mayo Clinic, Cochrane Library, Covance Laboratory and ASRM databases were used for collecting data in the form of case reports, research articles, reviews, clinical trials, journals, and books. Design: Out of 400 publications, 7 are shortlisted for their relevance to gynecological oncology and paleo nutrition interventions. Case reports and short-term clinical trials between year 2000-2020 are included for comparative analysis of Paleodiet and its variants with other nutritional interventions. Results: There is no scientific data that has been reported on genetic and molecular impacts of paleo-nutrition on gynecological cancers. Clinical reports suggest significant improvement through paleodiet intervention in anthropometric markers and metabolism in pre-treatment and post-treatment examination of patients of gynae-oncology. Very limited data is available for comparative analysis of paleodiet and other dietary interventions. Conclusion: Paleo nutrition is an under-researched future intervention and has a potential to impact treatment strategies for gynecological patients. A large volume of randomized controlled trials for each ethnic group can help manage the cancer burden globally.