鲜姜和黑荆提取物对电足刺激应激Wistar大鼠部分生化和免疫指标的影响

Chiamaka Maryann Nwarienne, G. E. Igbokwe, D. Ikwuka, U. M. Ezugwu, K. C. Ngobidi
{"title":"鲜姜和黑荆提取物对电足刺激应激Wistar大鼠部分生化和免疫指标的影响","authors":"Chiamaka Maryann Nwarienne, G. E. Igbokwe, D. Ikwuka, U. M. Ezugwu, K. C. Ngobidi","doi":"10.9734/jamps/2023/v25i8634","DOIUrl":null,"url":null,"abstract":"Stress in general captures the process that individuals experience when environmental demands exceed the capacity of an individual, there is consistent evidence that stress is associated with a variety of negative health outcomes which happens through a variety of mechanisms. The purpose of this study was to investigate the effects of Zingiber officinale and the seeds of Aframomum melegueta extracts on some biochemical and immunological indices of electric foot shock stress-induced Wistar rats. Forty-five Wistar rats were randomized into nine groups (A-I) of five rats per group. Group A served as standard control and was not induced with electric shock, group B served as negative control hence they were induced and untreated, group C served as the positive control and was administered 2.9 mg/kg magnesium while groups D and E were administered 100 and 200 mg/kg body weight of Zingiber officinale extract and groups F and G were administered 100 and 200 mg/kg body weight of Aframomum melegueta extract respectively, while co extract of Z. officinale and A. melegueta was administered to group H and I at a dose of 100 and 200 mg/kg body weight respectively. At the end of the experimental period, the animals were sacrificed and the sera obtained were used for bioassay analysis. There was a significant decrease (P<0.05) in the cortisol levels of extract-treated groups from week 1 (2.56±0.55 µg/dl) to week 4 (1.85±0.30 µg/dl) compared to the untreated group (3.98±0.69 µg/dl) (week 1) and (8.57±1.31 µg/dl) (week 4) as well as the kidney function test. The liver function test revealed a significant decrease in liver biomarkers (Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase, direct bilirubin,  and total bilirubin) in the extract-treated groups compared to the untreated control group.                   The extract of the plants impacted the White blood cell and its differentials while there was a significant decrease in the C-reactive protein in the extract-treated group (2.38±0.22 mg/l) compared to the untreated control (9.93±1.50 mg/l). The findings from this research showed that the extracts of Z. officinale and A. melegueta affects some biochemical and immunological parameters and hence could serve as a potential therapeutic agent to fight against stress and its related disorders.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Zingiber officinale and Seeds of Aframomum melegueta Extract on Some Biochemical and Immunological Indices of Electric Foot Shock Stress-Induced Wistar Rats\",\"authors\":\"Chiamaka Maryann Nwarienne, G. E. Igbokwe, D. Ikwuka, U. M. Ezugwu, K. C. Ngobidi\",\"doi\":\"10.9734/jamps/2023/v25i8634\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Stress in general captures the process that individuals experience when environmental demands exceed the capacity of an individual, there is consistent evidence that stress is associated with a variety of negative health outcomes which happens through a variety of mechanisms. The purpose of this study was to investigate the effects of Zingiber officinale and the seeds of Aframomum melegueta extracts on some biochemical and immunological indices of electric foot shock stress-induced Wistar rats. Forty-five Wistar rats were randomized into nine groups (A-I) of five rats per group. Group A served as standard control and was not induced with electric shock, group B served as negative control hence they were induced and untreated, group C served as the positive control and was administered 2.9 mg/kg magnesium while groups D and E were administered 100 and 200 mg/kg body weight of Zingiber officinale extract and groups F and G were administered 100 and 200 mg/kg body weight of Aframomum melegueta extract respectively, while co extract of Z. officinale and A. melegueta was administered to group H and I at a dose of 100 and 200 mg/kg body weight respectively. At the end of the experimental period, the animals were sacrificed and the sera obtained were used for bioassay analysis. There was a significant decrease (P<0.05) in the cortisol levels of extract-treated groups from week 1 (2.56±0.55 µg/dl) to week 4 (1.85±0.30 µg/dl) compared to the untreated group (3.98±0.69 µg/dl) (week 1) and (8.57±1.31 µg/dl) (week 4) as well as the kidney function test. The liver function test revealed a significant decrease in liver biomarkers (Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase, direct bilirubin,  and total bilirubin) in the extract-treated groups compared to the untreated control group.                   The extract of the plants impacted the White blood cell and its differentials while there was a significant decrease in the C-reactive protein in the extract-treated group (2.38±0.22 mg/l) compared to the untreated control (9.93±1.50 mg/l). The findings from this research showed that the extracts of Z. officinale and A. melegueta affects some biochemical and immunological parameters and hence could serve as a potential therapeutic agent to fight against stress and its related disorders.\",\"PeriodicalId\":14903,\"journal\":{\"name\":\"Journal of Advances in Medical and Pharmaceutical Sciences\",\"volume\":\"66 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advances in Medical and Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.9734/jamps/2023/v25i8634\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advances in Medical and Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/jamps/2023/v25i8634","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

压力通常是指个人在环境要求超出个人承受能力时所经历的过程。有一致的证据表明,压力与通过各种机制发生的各种负面健康结果有关。本研究旨在探讨鲜姜和苦楝种子提取物对电足刺激应激诱导Wistar大鼠部分生化和免疫指标的影响。45只Wistar大鼠随机分为9组(A-I),每组5只。A组为标准对照,不进行电击诱导,B组为阴性对照,诱导后不进行处理,C组为阳性对照,给予2.9 mg/kg镁,D组和E组分别给予100和200 mg/kg体重的生姜提取物,F组和G组分别给予100和200 mg/kg体重的金针菇提取物。H组和I组分别以100和200 mg/kg体重的剂量给药officinale和a . melegueta提取物。实验结束时,处死动物,所得血清用于生物测定分析。与未处理组(3.98±0.69µg/dl)(第1周)和(8.57±1.31µg/dl)(第4周)相比,提取物处理组第1周皮质醇水平(2.56±0.55µg/dl)至第4周皮质醇水平(1.85±0.30µg/dl)显著降低(P<0.05)。肝功能测试显示,与未治疗的对照组相比,提取物处理组的肝脏生物标志物(丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶、直接胆红素和总胆红素)显著降低。与未处理组(9.93±1.50 mg/l)相比,处理组(2.38±0.22 mg/l)的c反应蛋白显著降低(2.38±0.22 mg/l)。本研究结果表明,大戟天和大戟天提取物对机体的生化和免疫指标有一定的影响,可作为抗应激及其相关疾病的潜在药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Effects of Zingiber officinale and Seeds of Aframomum melegueta Extract on Some Biochemical and Immunological Indices of Electric Foot Shock Stress-Induced Wistar Rats
Stress in general captures the process that individuals experience when environmental demands exceed the capacity of an individual, there is consistent evidence that stress is associated with a variety of negative health outcomes which happens through a variety of mechanisms. The purpose of this study was to investigate the effects of Zingiber officinale and the seeds of Aframomum melegueta extracts on some biochemical and immunological indices of electric foot shock stress-induced Wistar rats. Forty-five Wistar rats were randomized into nine groups (A-I) of five rats per group. Group A served as standard control and was not induced with electric shock, group B served as negative control hence they were induced and untreated, group C served as the positive control and was administered 2.9 mg/kg magnesium while groups D and E were administered 100 and 200 mg/kg body weight of Zingiber officinale extract and groups F and G were administered 100 and 200 mg/kg body weight of Aframomum melegueta extract respectively, while co extract of Z. officinale and A. melegueta was administered to group H and I at a dose of 100 and 200 mg/kg body weight respectively. At the end of the experimental period, the animals were sacrificed and the sera obtained were used for bioassay analysis. There was a significant decrease (P<0.05) in the cortisol levels of extract-treated groups from week 1 (2.56±0.55 µg/dl) to week 4 (1.85±0.30 µg/dl) compared to the untreated group (3.98±0.69 µg/dl) (week 1) and (8.57±1.31 µg/dl) (week 4) as well as the kidney function test. The liver function test revealed a significant decrease in liver biomarkers (Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase, direct bilirubin,  and total bilirubin) in the extract-treated groups compared to the untreated control group.                   The extract of the plants impacted the White blood cell and its differentials while there was a significant decrease in the C-reactive protein in the extract-treated group (2.38±0.22 mg/l) compared to the untreated control (9.93±1.50 mg/l). The findings from this research showed that the extracts of Z. officinale and A. melegueta affects some biochemical and immunological parameters and hence could serve as a potential therapeutic agent to fight against stress and its related disorders.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Evaluating Compliance and Performance of 0.5 mL AD Syringes: A Global Standards Review Acute Toxicity, Antioxidant and Vasodilatory Properties of Sclerocarya birrea (A. rich.) Hochst (Anacardiaceae) Trunk Bark’s Aqueous Decoction Towards Effective Healthcare Delivery: An Assessment of Public Perception of Pharmacist’s Role in Nigeria Multiple Drug Resistance in Burn Patients In-Process Quality Checks and Post-Market Surveillance of Artemether-Lumefantrine Fixed-dose Combination Tablets and Suspensions: Current Procedures, Successes, Advances, and Challenges
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1