Serdar Nurmedov, O. Noyan, B. Metin, Sehadet Ekmen, Cumhur Avcil, S. Kose
{"title":"酒精使用障碍患者广泛的灰质体积减少及其与神经心理表现的相关性","authors":"Serdar Nurmedov, O. Noyan, B. Metin, Sehadet Ekmen, Cumhur Avcil, S. Kose","doi":"10.5455/BCP.20160223123949","DOIUrl":null,"url":null,"abstract":"ABSTRACTObjective: Long term alcohol use results in varying degrees of deficits in cognitive functions. Although the neocortex, particularly the frontal lobe; limbic system and cerebellum are the brain regions most vulnerable to the toxic effects of alcohol, neural correlates of neuropsychological deficits have not been studied directly.Methods: This voxel based morphometric (VBM) study examined the effect of duration and amount of alcohol exposure on gray matter (GM) volume and the relation between GM volumes and neuropsychological deficits in patients with Alcohol Use Disorder (AUD).Results: Voxel-wise whole brain analysis showed extensive regional gray matter volume for AUD patients and GM volumes were inversely correlated to the amount of alcohol exposure. More importantly, there were statistically significant correlations between different indices of executive functioning and GM volumes.Conclusion: These results indicate that dose-dependent alcohol effect on prefrontostriatal and temporal circuitries...","PeriodicalId":17852,"journal":{"name":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Extensive Gray Matter Volume Reduction and Correlations with Neuropsychological Performance in Alcohol Use Disorder Patients\",\"authors\":\"Serdar Nurmedov, O. Noyan, B. Metin, Sehadet Ekmen, Cumhur Avcil, S. Kose\",\"doi\":\"10.5455/BCP.20160223123949\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACTObjective: Long term alcohol use results in varying degrees of deficits in cognitive functions. Although the neocortex, particularly the frontal lobe; limbic system and cerebellum are the brain regions most vulnerable to the toxic effects of alcohol, neural correlates of neuropsychological deficits have not been studied directly.Methods: This voxel based morphometric (VBM) study examined the effect of duration and amount of alcohol exposure on gray matter (GM) volume and the relation between GM volumes and neuropsychological deficits in patients with Alcohol Use Disorder (AUD).Results: Voxel-wise whole brain analysis showed extensive regional gray matter volume for AUD patients and GM volumes were inversely correlated to the amount of alcohol exposure. More importantly, there were statistically significant correlations between different indices of executive functioning and GM volumes.Conclusion: These results indicate that dose-dependent alcohol effect on prefrontostriatal and temporal circuitries...\",\"PeriodicalId\":17852,\"journal\":{\"name\":\"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/BCP.20160223123949\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/BCP.20160223123949","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
Extensive Gray Matter Volume Reduction and Correlations with Neuropsychological Performance in Alcohol Use Disorder Patients
ABSTRACTObjective: Long term alcohol use results in varying degrees of deficits in cognitive functions. Although the neocortex, particularly the frontal lobe; limbic system and cerebellum are the brain regions most vulnerable to the toxic effects of alcohol, neural correlates of neuropsychological deficits have not been studied directly.Methods: This voxel based morphometric (VBM) study examined the effect of duration and amount of alcohol exposure on gray matter (GM) volume and the relation between GM volumes and neuropsychological deficits in patients with Alcohol Use Disorder (AUD).Results: Voxel-wise whole brain analysis showed extensive regional gray matter volume for AUD patients and GM volumes were inversely correlated to the amount of alcohol exposure. More importantly, there were statistically significant correlations between different indices of executive functioning and GM volumes.Conclusion: These results indicate that dose-dependent alcohol effect on prefrontostriatal and temporal circuitries...