临床微生物学和传染病预防算法中的生物信息学工具

Hyunjo Kim
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引用次数: 4

摘要

生物信息学资源是指用于诊断、治疗和预防目的的基因组序列数据的开发。临床基因组学在传染病中的作用旨在描述暴发群落的结构,其方法同样适用于识别临床样本中的病原体。此外,在疫情暴发中早期发现传染病是综合征监测系统的重要问题之一。使用临床基因组学方法的关键概念是生成大规模序列数据集的过程,这些数据集可以充分采样样品中的微生物含量,然后应用计算方法将序列分解为个体物种,基因,途径或其他特征。它有助于提供快速流行病学反应并降低发病率和死亡率。因此,从耐药性的角度考虑病毒传播和预防的生物信息学模型算法。未来对抵抗组的相关研究揭示了可用于新抗生素发现的策略。
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Bioinformatics Tools in Clinical Microbiology and Infectious Disease Prevention Algorithms
Bioinformatics resource is the exploitation of genome sequence data for diagnostic, therapeutic, and preventionpurposes. The role of clinical genomics in infectious disease is aimed at describing the structure of outbreakcommunities, the methodology works equally well to identify pathogens in clinical samples. Furthermore, early detectionof infectious disease in outbreaks is one of the significant issues in syndromic surveillance systems. The key concept inusing clinical genomics methodology is a process of generating large-scale sequence data sets that adequately samplea specimen for microbial content and then of applying computational methods to resolve the sequences into individualspecies, genes, pathways, or other features. It helps to provide a rapid epidemiological response and reduce morbidityand mortality. Therefore, bioinformatics model algorithms for virus transmission and prevention in terms of resistomewould be taken into consideration. The relevant future study of resistome reveals strategies that can be applied in newantibiotic discoveries.
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