C. Boutin, Y. Roche, R. Jaffiol, J. Millot, C. Millot, J. Plain, R. Déturche, P. Jeannesson, M. Manfait, P. Royer
{"title":"荧光相关光谱显示不同药物对多药耐药细胞的影响","authors":"C. Boutin, Y. Roche, R. Jaffiol, J. Millot, C. Millot, J. Plain, R. Déturche, P. Jeannesson, M. Manfait, P. Royer","doi":"10.1051/ANPHYS:2008027","DOIUrl":null,"url":null,"abstract":"Fluorescence correlation spectroscopy (FCS) has been used to analyze the plasma membrane fluidity and heterogene- ity of multidrug resistant cells. At the single cell level, the effects of different membrane agents present in the extra-cellular medium have been explored. Firstly, we reveal a modification of plasma membrane heterogeneities according to the addition of a fluidity modulator, benzyl alcohol. On the other hand, revertants such as verapamil and cyclosporin-A appear to act more specifically on the slow diffusion sites, such as lipids microdomains.","PeriodicalId":50779,"journal":{"name":"Annales De Physique","volume":"10 1","pages":"139-141"},"PeriodicalIF":0.0000,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Effect of different agents onto multidrug resistant cells revealed by fluorescence correlation spectroscopy\",\"authors\":\"C. Boutin, Y. Roche, R. Jaffiol, J. Millot, C. Millot, J. Plain, R. Déturche, P. Jeannesson, M. Manfait, P. Royer\",\"doi\":\"10.1051/ANPHYS:2008027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Fluorescence correlation spectroscopy (FCS) has been used to analyze the plasma membrane fluidity and heterogene- ity of multidrug resistant cells. At the single cell level, the effects of different membrane agents present in the extra-cellular medium have been explored. Firstly, we reveal a modification of plasma membrane heterogeneities according to the addition of a fluidity modulator, benzyl alcohol. On the other hand, revertants such as verapamil and cyclosporin-A appear to act more specifically on the slow diffusion sites, such as lipids microdomains.\",\"PeriodicalId\":50779,\"journal\":{\"name\":\"Annales De Physique\",\"volume\":\"10 1\",\"pages\":\"139-141\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales De Physique\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1051/ANPHYS:2008027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales De Physique","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1051/ANPHYS:2008027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of different agents onto multidrug resistant cells revealed by fluorescence correlation spectroscopy
Fluorescence correlation spectroscopy (FCS) has been used to analyze the plasma membrane fluidity and heterogene- ity of multidrug resistant cells. At the single cell level, the effects of different membrane agents present in the extra-cellular medium have been explored. Firstly, we reveal a modification of plasma membrane heterogeneities according to the addition of a fluidity modulator, benzyl alcohol. On the other hand, revertants such as verapamil and cyclosporin-A appear to act more specifically on the slow diffusion sites, such as lipids microdomains.
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