质子放射照相用核乳剂膜探测器:第一个原型的设计和测试

S. Braccini, A. Ereditato, I. Kreslo, U. Moser, C. Pistillo, P. Scampoli, S. Studer
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引用次数: 2

摘要

质子治疗如今已成为癌症治疗中广泛应用的临床实践,复杂的治疗计划系统通常用于至多利用带电粒子的弹道特性。关于光束质量和质子范围的信息是优化治疗的关键问题。为此,质子放射照相可用于质子治疗,以获得关于质子范围的直接信息,关于组织的平均密度,以优化治疗计划,并对患者进行可忽略剂量的成像。我们提出了一种基于核乳剂膜探测器的质子放射成像的创新方法,该方法通过测量穿过患者身体的质子的位置和残余范围来获得图像。与组织等效吸收剂交织的核乳剂膜可以有效地用于重建质子轨迹,具有很高的精度。第一个原型的核乳液为基础的探测器已经构思,构造和测试与治疗质子束在PSI。在伯尔尼的LHEP上对乳剂进行了扫描,在那里,为中微子振荡的OPERA实验开发了一种全自动显微扫描技术。在轨迹重建后,通过对一个步长为1cm的简单PMMA模体进行成像,获得了第一个有希望的实验结果。第二个幻影是5个5 × 5 mm^2截面的铝棒,位于不同的距离,并嵌入在PMMA结构中,也被成像。进一步的研究正在进行中,以提高分辨率和成像更复杂的幽灵。
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Nuclear Emulsion Film Detectors for Proton Radiography: Design and Test of the First Prototype
Proton therapy is nowadays becoming a wide spread clinical practice in cancer therapy and sophisticated treatment planning systems are routinely used to exploit at best the ballistic properties of charged particles. The information on the quality of the beams and the range of the protons is a key issue for the optimization of the treatment. For this purpose, proton radiography can be used in proton therapy to obtain direct information on the range of the protons, on the average density of the tissues for treatment planning optimization and to perform imaging with negligible dose to the patient. We propose an innovative method based on nuclear emulsion film detectors for proton radiography, a technique in which images are obtained by measuring the position and the residual range of protons passing through the patient's body. Nuclear emulsion films interleaved with tissue equivalent absorbers can be fruitfully used to reconstruct proton tracks with very high precision. The first prototype of a nuclear emulsion based detector has been conceived, constructed and tested with a therapeutic proton beam at PSI. The scanning of the emulsions has been performed at LHEP in Bern, where a fully automated microscopic scanning technology has been developed for the OPERA experiment on neutrino oscillations. After track reconstruction, the first promising experimental results have been obtained by imaging a simple phantom made of PMMA with a step of 1 cm. A second phantom with five 5 x 5 mm^2 section aluminum rods located at different distances and embedded in a PMMA structure has been also imaged. Further investigations are in progress to improve the resolution and to image more sophisticated phantoms.
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