{"title":"脑室-腹膜分流术对继发性常压脑积水的显著改善","authors":"H. Onder, Umut Doğu Aktürk","doi":"10.14740/jnr545","DOIUrl":null,"url":null,"abstract":"A 60-year-old male patient was admitted to our clinic with symptoms of gait difficulty, urinary incontinence, and cognitive impairment which had started over the last 5 years and gradually progressed. So he had to use unilateral support for outdoor activities over the last 1-year period. Besides, he had severe symptoms of urinary incontinence and had to use underpads for a long time. Upon interrogation of medical history, it was learned that he had been hospitalized in the intensive care unit for 1 month due to post-traumatic subarachnoid hemorrhage (SAH) and right frontal hemorrhage which had occurred due to motor vehicle accident 40 years ago. At admission to our clinic, he was orientated and cooperative. However, it was noticed that the patient was uninterested to the interview and slowing in the reaction time was apparent. He was not willing to state his symptoms and rather did not speak spontaneously which was compatible with apathetic state. Neurological examinations of the pyramidal, sensory and cerebellar functions were within normal limits. However, gait was evaluated as wide-based, short-stepped, slow and shuffling. He had difficulty particularly during turning, and episodes of freezing of gait were apparent (Video images are unavailable due to technical problems). Standardized mini-mental test (SMMT) score was evaluated as 19 points. Cranial magnetic resonance imaging (MRI) showed left frontal encephalomalacia and non-obstructive hydrocephalus (Fig. 1). Taken together, normal pressure hydrocephalus was considered at the forefront, and cerebrospinal fluid (CSF) tap test (TT) was suggested. CSF opening pressure was 10 cm H2O, and 40 mL CSF was drained which provided a temporary, significant improvement in the patient’s locomotion and symptoms of urinary incontinence. Taken together, the diagnosis of secondary normal pressure hydrocephalus (sNPH) was established. The patient and his relatives were informed about the disease, and ventriculoperitoneal shunt (VP) surgery was suggested. After taking informed consent, surgery was performed. Following VP shunt, a significant recovery in the gait and cognitive symptoms were achieved. Cranial computed tomography performed 1 week after shunt surgery, showed an intact shunt (Fig. 2). On the second month of follow-up after surgery, he had no longer need for support, and all the parameters of his gait improved dramatically (Supplementary video 1, www. neurores.org). Urinary continence symptoms were nearly over. His perception and communication, as well as interest had improved significantly and he got 24 points on SMMT. Approximately, 50% of the normal pressure hydrocephalus (NPH) cases occur in association with prior events that cause the development of this syndrome [1]. In the recent crucial report by Daou et al, it was concluded that sNPH should be differentiated from idiopathic NPH (iNPH) based on outcome and on clinical, pathophysiological, and epidemiological characteristics, but should not be considered as a separate entity [2]. The better response to shunt surgery in sNPH (in comparison to iNPH) has also been emphasized in other studies [3]. The diagnosis of sNPH is based on a combination of clinical history, physical examination, and imaging studies [2]. In our patient, the clinical presentation was characterized by the classic triad of dementia, gait disturbance, and urinary incontinence. Besides, cranial MRI showed hydrocephalus and CSF TT provided a significant improvement (and CSF opening pressure was normal). The remarkable point was that he had a history of traumatic SAH and parenchymal hemorrhage 40 years ago, but clinical symptoms were rather recognized over the last 5 years. Considering the long interval between the event of trauma and clinical onset of symptoms, we think that it may be challenging to conclude a clear causal association between these two occurrences. It has been indicated that for diagnosis of sNPH, there should be a well-established event to induce NPH and the clinical manifestations generally should begin immediately or several months after the event. However, the time required for the development of NPH after the inducer event (SAH, trauma, meningitis, stroke, tumors, etc.) has not been established properly. Combining the clinical manifestations, medical history of a traumatic brain injury and clear evidence in neuroimaging, we have established the final diagnosis of sNPH. In accordance with the literature data, a dramatic improvement was obtained following VP shunt surgery, such that his gait problems were determined to be totally resolved on the second month of follow-up. At this point, we would like to state that in our province with a population of approximately 500,000, our clinic is a senior center where the substantial rate of the patients with suspicion of NPH is evalManuscript submitted June 26, 2019, accepted August 5, 2019","PeriodicalId":16489,"journal":{"name":"Journal of Neurology Research","volume":"35 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Dramatic Improvement by Ventriculoperitoneal Shunt Surgery in a Patient With Secondary Normal Pressure Hydrocephalus\",\"authors\":\"H. Onder, Umut Doğu Aktürk\",\"doi\":\"10.14740/jnr545\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 60-year-old male patient was admitted to our clinic with symptoms of gait difficulty, urinary incontinence, and cognitive impairment which had started over the last 5 years and gradually progressed. So he had to use unilateral support for outdoor activities over the last 1-year period. Besides, he had severe symptoms of urinary incontinence and had to use underpads for a long time. Upon interrogation of medical history, it was learned that he had been hospitalized in the intensive care unit for 1 month due to post-traumatic subarachnoid hemorrhage (SAH) and right frontal hemorrhage which had occurred due to motor vehicle accident 40 years ago. At admission to our clinic, he was orientated and cooperative. However, it was noticed that the patient was uninterested to the interview and slowing in the reaction time was apparent. He was not willing to state his symptoms and rather did not speak spontaneously which was compatible with apathetic state. Neurological examinations of the pyramidal, sensory and cerebellar functions were within normal limits. However, gait was evaluated as wide-based, short-stepped, slow and shuffling. He had difficulty particularly during turning, and episodes of freezing of gait were apparent (Video images are unavailable due to technical problems). Standardized mini-mental test (SMMT) score was evaluated as 19 points. Cranial magnetic resonance imaging (MRI) showed left frontal encephalomalacia and non-obstructive hydrocephalus (Fig. 1). Taken together, normal pressure hydrocephalus was considered at the forefront, and cerebrospinal fluid (CSF) tap test (TT) was suggested. CSF opening pressure was 10 cm H2O, and 40 mL CSF was drained which provided a temporary, significant improvement in the patient’s locomotion and symptoms of urinary incontinence. Taken together, the diagnosis of secondary normal pressure hydrocephalus (sNPH) was established. The patient and his relatives were informed about the disease, and ventriculoperitoneal shunt (VP) surgery was suggested. After taking informed consent, surgery was performed. Following VP shunt, a significant recovery in the gait and cognitive symptoms were achieved. Cranial computed tomography performed 1 week after shunt surgery, showed an intact shunt (Fig. 2). On the second month of follow-up after surgery, he had no longer need for support, and all the parameters of his gait improved dramatically (Supplementary video 1, www. neurores.org). Urinary continence symptoms were nearly over. His perception and communication, as well as interest had improved significantly and he got 24 points on SMMT. Approximately, 50% of the normal pressure hydrocephalus (NPH) cases occur in association with prior events that cause the development of this syndrome [1]. In the recent crucial report by Daou et al, it was concluded that sNPH should be differentiated from idiopathic NPH (iNPH) based on outcome and on clinical, pathophysiological, and epidemiological characteristics, but should not be considered as a separate entity [2]. The better response to shunt surgery in sNPH (in comparison to iNPH) has also been emphasized in other studies [3]. The diagnosis of sNPH is based on a combination of clinical history, physical examination, and imaging studies [2]. In our patient, the clinical presentation was characterized by the classic triad of dementia, gait disturbance, and urinary incontinence. Besides, cranial MRI showed hydrocephalus and CSF TT provided a significant improvement (and CSF opening pressure was normal). The remarkable point was that he had a history of traumatic SAH and parenchymal hemorrhage 40 years ago, but clinical symptoms were rather recognized over the last 5 years. Considering the long interval between the event of trauma and clinical onset of symptoms, we think that it may be challenging to conclude a clear causal association between these two occurrences. It has been indicated that for diagnosis of sNPH, there should be a well-established event to induce NPH and the clinical manifestations generally should begin immediately or several months after the event. However, the time required for the development of NPH after the inducer event (SAH, trauma, meningitis, stroke, tumors, etc.) has not been established properly. Combining the clinical manifestations, medical history of a traumatic brain injury and clear evidence in neuroimaging, we have established the final diagnosis of sNPH. In accordance with the literature data, a dramatic improvement was obtained following VP shunt surgery, such that his gait problems were determined to be totally resolved on the second month of follow-up. At this point, we would like to state that in our province with a population of approximately 500,000, our clinic is a senior center where the substantial rate of the patients with suspicion of NPH is evalManuscript submitted June 26, 2019, accepted August 5, 2019\",\"PeriodicalId\":16489,\"journal\":{\"name\":\"Journal of Neurology Research\",\"volume\":\"35 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurology Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14740/jnr545\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurology Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/jnr545","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
一位60岁男性患者因步态困难、尿失禁、认知障碍等症状于近5年开始并逐渐恶化而入院。所以在过去的一年里,他必须使用单边支持来进行户外活动。此外,他有严重的尿失禁症状,不得不长时间使用衬垫。经询问病史得知,40年前因机动车事故造成创伤后蛛网膜下腔出血(SAH)和右额出血,曾在重症监护室住过1个月。在我们的诊所,他是有方向的和合作。然而,我们注意到病人对面试不感兴趣,反应时间明显变慢。他不愿意陈述自己的症状,更不愿意自发地说话,这与冷漠状态相一致。神经学检查锥体、感觉和小脑功能均在正常范围内。然而,步态被评估为宽基,短步,缓慢和拖沓。他有困难,特别是在转身时,步态明显冻结(由于技术问题,无法获得视频图像)。标准迷你心理测验(SMMT)得分为19分。颅脑磁共振(MRI)显示左侧额叶性脑软化,非梗阻性脑积水(图1)。综合考虑常压脑积水,建议行脑脊液(CSF) tap test (TT)。脑脊液开口压力为10 cm H2O,排出40 mL脑脊液,可暂时显著改善患者的运动和尿失禁症状。综上所述,继发性常压脑积水(sNPH)的诊断得以确立。告知患者及其亲属病情,建议行脑室-腹膜分流术(VP)。在获得知情同意后,进行手术。在静脉静脉分流术后,步态和认知症状明显恢复。在分流手术后1周进行颅脑计算机断层扫描,显示一个完整的分流(图2)。在手术后第二个月的随访中,他不再需要支持,他的步态的所有参数显著改善(补充视频1,www。neurores.org)。尿失禁的症状差不多结束了他的感知、沟通和兴趣都有了明显的提高,在SMMT上得到了24分。大约50%的正常压力性脑积水(NPH)病例与导致该综合征发展的先前事件有关。在Daou等人最近的重要报告中,他们得出结论,sNPH应根据结果以及临床、病理生理和流行病学特征与特发性NPH (iNPH)区分开来,但不应将其视为一个单独的实体[10]。其他研究也强调了sNPH患者对分流手术的更好反应(与iNPH患者相比)。sNPH的诊断是基于临床病史、体格检查和影像学检查[b]。在我们的患者中,临床表现的特点是痴呆,步态障碍和尿失禁的经典三联征。头颅MRI显示脑积水,脑脊液TT明显改善(脑脊液开口压力正常)。值得注意的是,他在40年前有创伤性SAH和实质出血的病史,但临床症状在最近5年才得到确认。考虑到创伤事件与临床症状发作之间的时间间隔较长,我们认为在这两种事件之间得出明确的因果关系可能具有挑战性。有研究表明,对于sNPH的诊断,应该有一个确定的事件来诱发NPH,临床表现通常应该在事件发生后立即或几个月开始。然而,诱导剂事件(SAH、创伤、脑膜炎、中风、肿瘤等)发生后NPH发展所需的时间尚未得到适当的确定。结合临床表现,创伤性脑损伤的病史和明确的神经影像学证据,我们确定了sNPH的最终诊断。根据文献资料,在VP分流手术后获得了显着的改善,因此在随访的第二个月确定他的步态问题完全解决。在此,我们想说明的是,在我省人口约50万的情况下,我们的诊所是一个老年中心,疑似NPH患者的比例很高
A Dramatic Improvement by Ventriculoperitoneal Shunt Surgery in a Patient With Secondary Normal Pressure Hydrocephalus
A 60-year-old male patient was admitted to our clinic with symptoms of gait difficulty, urinary incontinence, and cognitive impairment which had started over the last 5 years and gradually progressed. So he had to use unilateral support for outdoor activities over the last 1-year period. Besides, he had severe symptoms of urinary incontinence and had to use underpads for a long time. Upon interrogation of medical history, it was learned that he had been hospitalized in the intensive care unit for 1 month due to post-traumatic subarachnoid hemorrhage (SAH) and right frontal hemorrhage which had occurred due to motor vehicle accident 40 years ago. At admission to our clinic, he was orientated and cooperative. However, it was noticed that the patient was uninterested to the interview and slowing in the reaction time was apparent. He was not willing to state his symptoms and rather did not speak spontaneously which was compatible with apathetic state. Neurological examinations of the pyramidal, sensory and cerebellar functions were within normal limits. However, gait was evaluated as wide-based, short-stepped, slow and shuffling. He had difficulty particularly during turning, and episodes of freezing of gait were apparent (Video images are unavailable due to technical problems). Standardized mini-mental test (SMMT) score was evaluated as 19 points. Cranial magnetic resonance imaging (MRI) showed left frontal encephalomalacia and non-obstructive hydrocephalus (Fig. 1). Taken together, normal pressure hydrocephalus was considered at the forefront, and cerebrospinal fluid (CSF) tap test (TT) was suggested. CSF opening pressure was 10 cm H2O, and 40 mL CSF was drained which provided a temporary, significant improvement in the patient’s locomotion and symptoms of urinary incontinence. Taken together, the diagnosis of secondary normal pressure hydrocephalus (sNPH) was established. The patient and his relatives were informed about the disease, and ventriculoperitoneal shunt (VP) surgery was suggested. After taking informed consent, surgery was performed. Following VP shunt, a significant recovery in the gait and cognitive symptoms were achieved. Cranial computed tomography performed 1 week after shunt surgery, showed an intact shunt (Fig. 2). On the second month of follow-up after surgery, he had no longer need for support, and all the parameters of his gait improved dramatically (Supplementary video 1, www. neurores.org). Urinary continence symptoms were nearly over. His perception and communication, as well as interest had improved significantly and he got 24 points on SMMT. Approximately, 50% of the normal pressure hydrocephalus (NPH) cases occur in association with prior events that cause the development of this syndrome [1]. In the recent crucial report by Daou et al, it was concluded that sNPH should be differentiated from idiopathic NPH (iNPH) based on outcome and on clinical, pathophysiological, and epidemiological characteristics, but should not be considered as a separate entity [2]. The better response to shunt surgery in sNPH (in comparison to iNPH) has also been emphasized in other studies [3]. The diagnosis of sNPH is based on a combination of clinical history, physical examination, and imaging studies [2]. In our patient, the clinical presentation was characterized by the classic triad of dementia, gait disturbance, and urinary incontinence. Besides, cranial MRI showed hydrocephalus and CSF TT provided a significant improvement (and CSF opening pressure was normal). The remarkable point was that he had a history of traumatic SAH and parenchymal hemorrhage 40 years ago, but clinical symptoms were rather recognized over the last 5 years. Considering the long interval between the event of trauma and clinical onset of symptoms, we think that it may be challenging to conclude a clear causal association between these two occurrences. It has been indicated that for diagnosis of sNPH, there should be a well-established event to induce NPH and the clinical manifestations generally should begin immediately or several months after the event. However, the time required for the development of NPH after the inducer event (SAH, trauma, meningitis, stroke, tumors, etc.) has not been established properly. Combining the clinical manifestations, medical history of a traumatic brain injury and clear evidence in neuroimaging, we have established the final diagnosis of sNPH. In accordance with the literature data, a dramatic improvement was obtained following VP shunt surgery, such that his gait problems were determined to be totally resolved on the second month of follow-up. At this point, we would like to state that in our province with a population of approximately 500,000, our clinic is a senior center where the substantial rate of the patients with suspicion of NPH is evalManuscript submitted June 26, 2019, accepted August 5, 2019