{"title":"诱导性多潜能干细胞(iPS)的研究现状和展望","authors":"陈凌懿, 刘林","doi":"10.1360/ZC2009-39-7-621","DOIUrl":null,"url":null,"abstract":"诱导多潜能性干细胞(induced pluripotent stem cells, iPS细胞)是通过在分化的体细胞中表达特定的几个转录因子, 以诱导体细胞的重编程而获得的可不断自我更新(self-renewal)且具有多向分化潜能的细胞. 由于iPS既避免免疫排斥, 又不涉及伦理道德问题, 因此具有广泛且重要的临床应用价值. 自从2006年Takahashi和Yamanaka报道成功地建立小鼠的iPS细胞以来, 全世界众多实验室开始了iPS细胞研究, 并取得了巨大进展. 本文回顾过去几年内在iPS细胞研究领域中的新发现, 包括建立iPS细胞的方法、iPS细胞形成的分子机制和iPS细胞的应用, 并探讨该领域中急需解决的问题和发展前景.","PeriodicalId":49127,"journal":{"name":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","volume":"37 1","pages":"621-635"},"PeriodicalIF":0.0000,"publicationDate":"2009-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"诱导性多潜能干细胞(iPS)的研究现状和展望\",\"authors\":\"陈凌懿, 刘林\",\"doi\":\"10.1360/ZC2009-39-7-621\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"诱导多潜能性干细胞(induced pluripotent stem cells, iPS细胞)是通过在分化的体细胞中表达特定的几个转录因子, 以诱导体细胞的重编程而获得的可不断自我更新(self-renewal)且具有多向分化潜能的细胞. 由于iPS既避免免疫排斥, 又不涉及伦理道德问题, 因此具有广泛且重要的临床应用价值. 自从2006年Takahashi和Yamanaka报道成功地建立小鼠的iPS细胞以来, 全世界众多实验室开始了iPS细胞研究, 并取得了巨大进展. 本文回顾过去几年内在iPS细胞研究领域中的新发现, 包括建立iPS细胞的方法、iPS细胞形成的分子机制和iPS细胞的应用, 并探讨该领域中急需解决的问题和发展前景.\",\"PeriodicalId\":49127,\"journal\":{\"name\":\"Science in China. Series C, Life Sciences / Chinese Academy of Sciences\",\"volume\":\"37 1\",\"pages\":\"621-635\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science in China. Series C, Life Sciences / Chinese Academy of Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1360/ZC2009-39-7-621\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science in China. Series C, Life Sciences / Chinese Academy of Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1360/ZC2009-39-7-621","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}