不同PCOS表型对ART周期中卵母细胞能力的影响

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY Journal of Clinical Obstetrics and Gynecology Pub Date : 2022-06-14 DOI:10.29328/journal.cjog.1001110
J. Namita, Malik Sonia, P. Ved
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引用次数: 1

摘要

简介:多囊卵巢综合征是女性不孕症的常见原因。尽管PCOS患者的特点是产生更多的卵母细胞,但它们的质量往往较差,导致受精率、卵裂率和着床率较低,流产率较高。目的:本研究旨在确定在ART周期中各种PCOS表型对卵母细胞能力的影响。背景和设计:回顾性观察性研究。方法与材料:研究组纳入102例以多囊卵巢综合征(PCOS)为主要不孕原因的妇女。数据收集时间为一年(2017-18年)。根据PCOS表型(A-D)将这些女性分为四组,并记录相关临床数据和ART结果。采用SPSS统计软件包进行统计分析。数据以均数±标准差表示,采用方差分析(ANOVA)进行比较。p值< 0.05认为有统计学意义。结果:102例PCOS患者中,A型占23.52%,B型占11.76%,C型占45.09%,D型占19.60%。与其他各组相比,B组形成的胚胎质量较低(p值0.01)。然而,所有组的临床妊娠率是相似的。结论:PCOS患者的生殖潜能随卵母细胞健康状况的变化而变化,在很大程度上取决于PCOS的表型。B型多囊卵巢综合征的女性在卵母细胞数量和胚胎形成方面可能有较差的IVF/ICSI结果。在卵母细胞数量和胚胎质量方面,PCO形态可能具有优势。高雄激素症合并慢性无排卵似乎与卵母细胞能力差有关,从而对胚胎质量和临床妊娠率产生负面影响。需要更大样本量的进一步研究来进一步支持它。关键信息:不同多囊卵巢综合征表型的卵母细胞能力。
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Impact of various PCOS phenotypes on oocyte competence in an ART cycle
Introduction: PCOS is a common cause of female infertility. Although PCOS patients are characterized by producing an increased number of oocytes, they are often of poor quality, leading to lower fertilization, cleavage, and implantation and higher miscarriage rates. Aims: The present study aims to identify the effect of various PCOS phenotypes on oocyte competence in an ART cycle. Settings and design: A retrospective observational study. Methods and material: The study group included 102 women with PCOS as a main cause of infertility. Data was collected over a period of one year (2017-18). These women were divided into four groups on basis of PCOS phenotypes (A-D) and the relevant clinical data and the ART outcome were noted. Statistical analysis was done using SPSS statistical package. Data presented as mean ± SD which was compared using the ANOVA test. A p - value < 0.05 was considered statistically significant. Results: Out of 102 PCOS women, 23.52% women had phenotype A, 11.76% had phenotype B, and 45.09% and 19.60% had phenotype C & D respectively. Good quality embryos formed (p - value 0.01) were lower in Group B vs. other groups. However, clinical pregnancy rates were comparable in all groups. Conclusion: The reproductive potential of women with PCOS varies with the oocyte health and it largely depends on PCOS phenotype. Women with PCOS phenotype B might have poor IVF/ICSI outcomes with regard to the number of oocytes retrieved and embryos formed. PCO morphology might carry an advantage with regards to the number of oocytes retrieved and better quality embryos. It seems that hyperandrogenism in combination with chronic anovulation is associated with poor oocyte competence and hence, a negative impact on embryo quality and clinical pregnancy rate. Further studies with a larger sample size are required to further support it. Key messages: Oocyte competence in various PCOS phenotypes.
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来源期刊
Journal of Clinical Obstetrics and Gynecology
Journal of Clinical Obstetrics and Gynecology Medicine-Obstetrics and Gynecology
CiteScore
0.30
自引率
0.00%
发文量
8
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