细菌性病原体在肾病患者中的流行及其新出现的耐药模式

Luisa Bono , Gioacchino Li Cavoli , Maria Stella Verde , Concetta Sodano , Calogera Tortorici , Angelo Ferrantelli , Tancredi Vincenzo Li Cavoli , Ugo Rotolo
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摘要

抗生素耐药性是当今一个全球性问题。了解细菌耐药趋势对经验性抗生素治疗至关重要。肾脏学实践满足微生物学兴趣的几个地点。我们的目的是研究细菌病原体的流行及其对常用抗生素的新耐药性模式。方法回顾性分析2009年1月至2013年12月肾内科住院患者的1249例微生物学报告。我们分析了首批鉴定的4种细菌病原体的抗生素敏感性模式。结果检出最多的病原菌为:大肠杆菌、金黄色葡萄球菌、粪肠球菌、铜绿假单胞菌、念珠菌、表皮葡萄球菌、肺炎克雷伯菌。广谱β -内酰胺酶产生菌大肠杆菌占37%,耐甲氧西林金黄色葡萄球菌占15%。结论病原菌对常用抗生素的耐药性呈上升趋势。我们对主要抗生素药敏型的细菌谱的报告使我们能够更合理地使用抗生素。
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Prevalence of bacterial pathogens and their emerging resistance patterns in patients with renal diseases

Background

Antibiotic resistance is a global problem today. The knowledge of bacterial resistances trend is crucial for antibiotic empiric therapy. Nephrology practice meets several sites of microbiological interest. We aimed to study the prevalence of bacterial pathogens and their emerging resistance patterns to antibiotics commonly used.

Methods

We reviewed 1249 microbiologic reports obtained between January 2009 and December 2013 from patients admitted to Nephrology Department. We analyzed the antibiotic susceptibility patterns for the firsts 4 identified bacterial pathogens.

Results

The bacterial pathogens most frequently isolated were: Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Candida, Staphylococcus epidermidis, Klebsiella pneumoniae. The percentage of extended spectrum beta-lactamase-producer Escherichia coli was 37% and methicillin-resistent Staphilococcus aureus was 15%.

Conclusion

Antibiotic resistance of bacterial pathogens to commonly used antibiotics is increasing. Our report on bacterial spectra of major antibiotic susceptibility patterns enables a more rational use.

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