从模式生物到有机体模型:可视化复杂的基因组数据集

Christoph W. Sensen
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引用次数: 1

摘要

基因组研究正迅速从线性信息(DNA和蛋白质分子)的特征扩展到包含空间和时间方面的信息(例如基因表达模式和蛋白质组学数据)。对这些复杂数据集的分析为生物信息学提出了新的挑战。一个主要的挑战是高度多样化的数据类型的整合,从基因功能和基因表达模式到蛋白质修饰,再到代谢网络。需要开发新技术来整合这些数据,并建立反映功能基因组学研究结果的细胞、组织、器官和整个生物体的多维模型。这些模型的可视化将对基因组研究的成功至关重要。
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From model organisms to organismal models: visualizing complex genomic datasets

Genome research is rapidly expanding from the characterization of linear information (DNA and protein molecules) to information that contains spatial and temporal aspects (for example gene expression patterns and proteomics data). The analysis of these complex data sets poses new challenges for bioinformatics. A major challenge is the integration of highly diverse data types, ranging from gene functions and gene expression patterns over protein modifications to metabolic networks. New technologies need to be developed to integrate these data and build multi-dimensional models of cells, tissues, organs and entire organisms that reflect the results of functional genomics studies. The visualization of these models will be crucial for the success of genome research.

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