当受到抑制时，对刺激的反应更灵敏

Science's STKE Pub Date : 2003-05-06 DOI:10.1126/scisignal.1812003tw182

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引用次数: 0

摘要

随着年龄的增长，皮质功能的衰退不仅发生在人类身上，也发生在猴子身上。皮质内抑制的退化可能是这些衰退的基础。Leventhal等人通过将γ-氨基丁酸(GABA)或GABA受体激动剂直接应用于老年猕猴初级视觉皮层的神经元来验证这一假设。这种处理改善了老年猴子神经元对视觉刺激的定向和方向选择性，但在年轻猴子中没有。A. G. Leventhal，王艳，濮明，周艳，马艳，GABA及其激动剂对衰老猴子视觉皮质功能的改善。科学通报，2003,32(2)。【摘要】【全文】

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More Responsive to Stimuli When Inhibited

The decline of cortical functions with age occurs not only in humans but also in monkeys. Degradation of intracortical inhibition may underlie these declines. Leventhal et al. tested this hypothesis by applying either γ-amino-butyric acid (GABA) or GABA receptor agonists directly on neurons in the primary visual cortex of old macaque monkeys. This treatment improved orientation and direction selectivity to visual stimuli in neurons of aged monkeys, but not in young ones. A. G. Leventhal, Y. Wang, M. Pu, Y. Zhou, Y. Ma, GABA and its agonists improved visual cortical function in senescent monkeys. Science 300, 812-815 (2003). [Abstract] [Full Text]

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