{"title":"棉籽蛋白消化性水解产物中的血管紧张素i转换酶抑制剂。","authors":"H. Ashida, K. Koida, K. Kanazawa, G. Danno","doi":"10.3136/FSTI9596T9798.3.257","DOIUrl":null,"url":null,"abstract":"The inhibitory peptides of angiotensin I-converting enzyme have been identified from cottonseed proteins. The inhibitory peptides in the pepsin hydrolyzate of cottonseed globulin were purified by successive chromatographies on CM-Sephadex C-50, Sephadex LH-20, and reversed phase high performance liquid chromatography using a C18 column. The amino acid sequences of inhibitory peptides were Tyr-Arg-Lys-Ile-Arg-Ser-Gln-Leu and Trp-Gln-His-Gln-Ser-Arg-Gly-Arg-Phe. The IC50 value of the former peptide was 3.8 μM and the latter was 27 μM.","PeriodicalId":12457,"journal":{"name":"Food Science and Technology International, Tokyo","volume":"31 1","pages":"257-258"},"PeriodicalIF":0.0000,"publicationDate":"1997-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Angiotensin I-Converting Enzyme Inhibitors from Peptic Hydrolyzate of Cottonseed Proteins.\",\"authors\":\"H. Ashida, K. Koida, K. Kanazawa, G. Danno\",\"doi\":\"10.3136/FSTI9596T9798.3.257\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The inhibitory peptides of angiotensin I-converting enzyme have been identified from cottonseed proteins. The inhibitory peptides in the pepsin hydrolyzate of cottonseed globulin were purified by successive chromatographies on CM-Sephadex C-50, Sephadex LH-20, and reversed phase high performance liquid chromatography using a C18 column. The amino acid sequences of inhibitory peptides were Tyr-Arg-Lys-Ile-Arg-Ser-Gln-Leu and Trp-Gln-His-Gln-Ser-Arg-Gly-Arg-Phe. The IC50 value of the former peptide was 3.8 μM and the latter was 27 μM.\",\"PeriodicalId\":12457,\"journal\":{\"name\":\"Food Science and Technology International, Tokyo\",\"volume\":\"31 1\",\"pages\":\"257-258\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science and Technology International, Tokyo\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3136/FSTI9596T9798.3.257\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science and Technology International, Tokyo","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3136/FSTI9596T9798.3.257","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Angiotensin I-Converting Enzyme Inhibitors from Peptic Hydrolyzate of Cottonseed Proteins.
The inhibitory peptides of angiotensin I-converting enzyme have been identified from cottonseed proteins. The inhibitory peptides in the pepsin hydrolyzate of cottonseed globulin were purified by successive chromatographies on CM-Sephadex C-50, Sephadex LH-20, and reversed phase high performance liquid chromatography using a C18 column. The amino acid sequences of inhibitory peptides were Tyr-Arg-Lys-Ile-Arg-Ser-Gln-Leu and Trp-Gln-His-Gln-Ser-Arg-Gly-Arg-Phe. The IC50 value of the former peptide was 3.8 μM and the latter was 27 μM.
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