Evaluation of the daily profile of blood pressure and features of hemodynamics in patients with hypertension and osteoarthritis

The objective is to assess the severity and features of arterial hypertension (AH) in patients who suffer from osteoarthritis (OA) using indicators of daily blood pressure monitoring (DBPM) and echocardiography (echoCG).Material and methods. According to the purpose and objectives of our dissertation research, a total of 130 people of different ages and genders with hypertension and OA were examined. Of these, group I included 60 patients with hypertension combined with OA. Group II consisted of 30 patients with hypertension without concomitant OA. Group III included 30 people with OA without concomitant hypertension. The control group consisted of 10 healthy people.Results. The results of the study show a burdened course of hypertension in the case of its combination with OA compared with patients with hypertension not combined with OA. The percentage of blood pressure in the subjects of group I is higher due to a slight decrease at night compared with patients of group II, in which there was a steady increase in blood pressure at night. Interventricular septal thickness rates in group I are 8% (p < 0,05) higher than in group II. Indicators of LА size in patients with combined pathology (group II) by 12,5% (p < 0,05) are higher than similar in patients with hypertension without concomitant OA (group I). The LV wall is moderately thickened in the subjects of group I, which is 9% (p < 0,05) higher than the same indicator in patients of group II, in whom the LV wall is slightly thickened. In the subjects of group III indicators corresponded to the norm or the upper limit of the norm. In addition, in patients of group I there is in inverse correlation (r = -0.31, p < 0.05) between the mean daily average daily blood pressure and ghrelin. An inverse correlation was also found between serum melatonin concentrations and average DBP data (r = -0.49, p < 0.05).Conclusions. The results of DBPM and echocardiography in patients with hypertension combined with OA indicate a mutually burdened course of these diseases, which increases the risk of complications from the cardiovascular system. Therefore, these non-invasive research methods can be used for early diagnosis of hypertension progression and selection of appropriate drug correction.