绿茶可以减少蛀牙和腐蚀:一项系统综述

Seyedeh-Fatemeh Seyedjavadi-Limoodi, N. Moghaddasi, F. Khosraviani, S. Pouya
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引用次数: 0

摘要

背景:近年来,有报道称使用含有绿茶提取物的漱口水可以预防蛀牙。在实验室研究中,GT已被证明是有效的控制牙菌斑和侵蚀。本综述的目的是在随机临床试验中评估GT提取物控制蛀牙和糜烂的有效性。方法:通过在Scopus、PubMed、WOS (Web of Science)数据库中检索相关关键词,以及在Google Scholar数据库中检索相关研究,提取2019年底前发表的英文随机临床试验(RCT)研究。然后,仔细审查符合条件的研究并提取所需的数据。结果:本研究共纳入12项符合条件的研究。本研究的纳入标准为人类RCT研究、英语语言和GT干预。该研究的排除标准为:缺乏阴性(安慰剂)或阳性对照组、检查GT衍生物效果的研究、口腔疾病(如牙周病)、接受正畸治疗的人、在研究前至少两周使用抗生素、方法学不完整、结果存在缺陷以及无法获得文章全文。GT组246人,安慰剂组157人,阳性对照组132人(氟化钠、氯己定、楝树提取物和益生菌)。11项研究使用GT漱口水,1项研究使用含有GT提取物的牙膏。在安慰剂组的研究中,GT对牙菌斑、口腔pH值、牙齿侵蚀的调节以及唾液变形链球菌和乳酸杆菌菌落数量的减少都有明显更好的效果。此外,GT对上述指标的调节作用与阳性对照组相似且具有可比性。结论:GT提取物具有抗龋、抗侵蚀作用。需要更大规模的随机临床试验来支持我们的发现。
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Green Tea May Reduce Dental Caries and Erosion: A Systematic Review
Background: In recent years, the use of mouthwashes containing green tea (GT) extract has been reported to prevent tooth decay. In laboratory studies, GT has been shown to be effective in controlling dental plaque and erosion. The aim of this review study was to evaluate the effectiveness of GT extract in controlling tooth decay and erosion in randomized clinical trials. Methods: By searching related keywords in the Scopus, PubMed, and WOS (Web of Science) databases, as well as searching for related studies in the Google Scholar database randomized clinical trial ( RCT) studies published in English by the end of 2019 were extracted. Then, eligible studies were carefully reviewed and the required data were extracted. Results: A total of 12 eligible studies were included in the study. The inclusion criteria of the study were human RCT studies, English language, and GT intervention. The exclusion criteria of the study were lack of negative (placebo) or positive control group, studies examining the effect of GT derivatives, oral diseases such as periodontal disease, people undergoing orthodontic treatment, use of antibiotics at least two weeks before the study, incomplete methodology, defects in the results, and lack of access to the full text of articles. The number of subjects was 246 in the GT group, 157 in the placebo group, and 132 in the positive control group (sodium fluoride, chlorhexidine, neem extract, and probiotic). Eleven studies used GT mouthwash and one study used toothpaste containing GT extract. In studies with placebo, GT showed a significantly better effect on dental plaque, oral pH, modulation of dental erosion, and reduction of the number salivary S. mutans and lactobacilli colonies. Additionally, GT had a similar and comparable effect to positive control groups in modulating the above-mentioned indices. Conclusion: GT extract can show anti-cariogenic and anti-erosive effects. Larger randomized clinical trials are needed to support our findings.
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