膳食硝酸盐和亚硝酸盐相互作用和维生素C、尿和血清硝酸盐和亚硝酸盐水平的调查:德黑兰脂质和葡萄糖研究

Z. Bahadoran, Zahra Saeedirad, M. Mousavi, P. Mirmiran, F. Azizi
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引用次数: 0

摘要

背景与目的:研究表明抗氧化剂可以阻止NO3/NO2转化为亚硝胺类化合物。本研究的目的是确定饮食中维生素C摄入量和NO3/NO2之间相互作用对尿液和血清NO3/NO2水平的潜在影响。材料和方法:这项横断面研究包括251名年龄>19岁的成年人,于2015年在德黑兰脂质和葡萄糖研究的第6期进行。采用半定量食物频率问卷评估食物摄入量。估算了每日硝酸盐、亚硝酸盐和维生素C的平均摄入量。用Grease法测定血清和尿液中硝酸盐和亚硝酸盐的水平。为了确定维生素C对尿和血清中硝酸盐和亚硝酸盐相互作用的影响,采用线性回归检验修正混杂因素的影响。结果:硝酸盐摄取量与其尿水平有显著相关性,高于维生素C摄取量的中位数(B = 0/004, p值= 0/004)。同样,在调整了年龄、性别、体重指数、卡路里摄入量后,这种相关性仍然显著(B = 0.03, p值= 0/001)。在调整后的硝酸盐和亚硝酸盐模型中,维生素C相互作用对硝酸盐摄入量和尿液水平的影响也很显著(B = 0/003 p值= 0/001)。结论:维生素C摄入量的增加可显著提高尿中硝酸盐的排泄量,在膳食摄入量与尿中硝酸盐排泄量的相互作用中是有效的。关键词:硝酸盐,亚硝酸盐,维生素C收稿日期:2018年12月4日收稿日期:2020年12月20日版权所有©2018库尔德斯坦医学科学大学出版。这是一篇在知识共享署名-非商业许可4.0 (CCBYNC)条款下发布的开放获取文章,允许下载,共享,重新混合,转换和构建作品,只要它被适当引用。未经《How》杂志许可,不得将该作品用于商业用途:Zahra Bahadoran, Zahra Saeedirad, Maryam Mousavi, Parvin Mirmiran, fereidoun Azizi。膳食硝酸盐和亚硝酸盐相互作用和维生素C、尿和血清硝酸盐和亚硝酸盐水平的调查:德黑兰脂质和葡萄糖研究。ُsjku 2021;26(6):57-68。
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Investigating of dietary nitrate and nitrite interaction and vitamin C and urinary and serum nitrate and nitrite levels: Tehran Lipid and Glucose Study
Background and Aim: studies show that antioxidants prevent conversion of NO3/NO2 to nitrosamines compounds. tha aim of this study was to determine the potential effect of interaction between dietary intakes of vitamin C and NO3/NO2 on urinary and serum levels of NO3/NO2. Materials and Methods: This cross-sectional study included 251 adults aged >19 years was performed in the phase 6 of the Tehran Lipid and Glucose Study in 2015. Food intake was assessed using a semi-quantitative food frequency questionnaire. The average daily intake of nitrate and nitrite and vitamin C was estimated. Serum and urine levels of nitrate and nitrite were measured using the Grease method. In order to determine the effect of vitamin C on the interaction of nitrate and nitrite in urine and serum, linear regression test was used to modify the effects of confounders. Results: There was a significant correlation between intake of nitrate and its urine level, above the median level of vitamin C intake (B = 0/004, P-value = 0/004). Also, this correlation remained significant after adjusting for age, sex, body mass index, calorie intake (B = 0.03, P-value = 0/001). The effect of vitamin C interactions on nitrate intake and urine level in the adjusted model for nitrate and nitrite was also found to be significant (B = 0/003 P-value = 0/001). Conclusion: Increased intake of vitamin C significantly increases urinary excretion of nitrate and it is effective in the interaction between dietary intakes and urinary excretion of nitrate. Keyword: nitrate, nitrite, vitamin C Received: Dec 4, 2018 Accepted: Dec 20, 2020 Copyright © 2018 the Author (s). Published by Kurdistan University of Medical Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBYNC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal How to cite the article: Zahra Bahadoran , Zahra Saeedirad , Maryam Mousavi , Parvin Mirmiran , fereidoun Azizi. Investigating of dietary nitrate and nitrite interaction and vitamin C and urinary and serum nitrate and nitrite levels: Tehran Lipid and Glucose Study. ُ ُSJKU 2021;26(6):57-68.
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