多层间充质干细胞细胞片的发育

J. Ochiai, Y. Niihara, J. Oliva
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引用次数: 0

摘要

在过去的十年里,细胞和基因疗法得到了巨大的发展。为了面对和适应这些新疗法的发展,美国食品和药物管理局(FDA)从2016年开始编写和更新新的指南,并不断更新。根据clinicaltrials.gov网站上注册的临床试验,间充质干细胞(MSCs)是治疗中使用最多的细胞,远远领先于诱导多能干细胞(iPSCs)。它们因其分化能力和抗炎作用而被广泛使用,但仍有一些争议需要明确的答案。需要进一步的研究来确定剂量、数量和注射途径(位置和移植方法),以及与自体间充质干细胞注射相比,同种异体间充质干细胞是否安全,包括它们的长期效果。本文就脂肪基质细胞在工程细胞片中的研究进展及其应用前景作一综述。
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Development of Multilayer Mesenchymal Stem Cell Cell Sheets
Cell and gene therapies have been developing dramatically over the past decade. To face and adapt to the development of these new therapies, the Food and Drug Administration (FDA) wrote and updated new guidelines from 2016 and keep updating them. Mesenchymal stem cells (MSCs) are the most used cells for treatment, far ahead from the induced pluripotent stem cells (iPSCs), based on registered clinical trials at clinicaltrials.gov. They are widely used because of their differentiation capacity and their anti-inflammatory properties, but some controversies still require clear answers. Additional studies are needed to determine the dosage, the number, and the route of injections (location and transplantation method), and if allogenic MSCs are safe compared to autologous MSC injection, including their long-term effect. In this review, we summarize the research our company is conducting with the adipose stromal cells in engineering cell sheets and their potential application.
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来源期刊
Journal of International Translational Medicine
Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
0.00%
发文量
317
审稿时长
8 weeks
期刊介绍: Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.
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