S. Esnault, J. Leet, M. Johansson, Karina T. Barretto, P. Fichtinger, F. J. Fogerty, K. Bernau, S. Mathur, D. Mosher, N. Sandbo, N. Jarjour
{"title":"免疫球蛋白G的嗜酸性细胞溶解与微管形成和rho相关蛋白激酶信号的抑制有关","authors":"S. Esnault, J. Leet, M. Johansson, Karina T. Barretto, P. Fichtinger, F. J. Fogerty, K. Bernau, S. Mathur, D. Mosher, N. Sandbo, N. Jarjour","doi":"10.1111/cea.13538","DOIUrl":null,"url":null,"abstract":"The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Cell‐free eosinophil granules are found in tissues in eosinophilic diseases, including asthma. This suggests that eosinophils have lysed and released cellular content, likely harming tissues.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"13 1","pages":"198 - 212"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":"{\"title\":\"Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho‐associated protein kinase signalling\",\"authors\":\"S. Esnault, J. Leet, M. Johansson, Karina T. Barretto, P. Fichtinger, F. J. Fogerty, K. Bernau, S. Mathur, D. Mosher, N. Sandbo, N. Jarjour\",\"doi\":\"10.1111/cea.13538\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Cell‐free eosinophil granules are found in tissues in eosinophilic diseases, including asthma. This suggests that eosinophils have lysed and released cellular content, likely harming tissues.\",\"PeriodicalId\":10148,\"journal\":{\"name\":\"Clinical & Experimental Allergy\",\"volume\":\"13 1\",\"pages\":\"198 - 212\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical & Experimental Allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/cea.13538\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical & Experimental Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/cea.13538","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho‐associated protein kinase signalling
The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Cell‐free eosinophil granules are found in tissues in eosinophilic diseases, including asthma. This suggests that eosinophils have lysed and released cellular content, likely harming tissues.