免疫球蛋白G的嗜酸性细胞溶解与微管形成和rho相关蛋白激酶信号的抑制有关

Clinical & Experimental Allergy Pub Date : 2019-11-21 DOI:10.1111/cea.13538

S. Esnault, J. Leet, M. Johansson, Karina T. Barretto, P. Fichtinger, F. J. Fogerty, K. Bernau, S. Mathur, D. Mosher, N. Sandbo, N. Jarjour

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引用次数: 11

摘要

气道中嗜酸性粒细胞的存在与哮喘严重程度和发作风险相关。无细胞嗜酸性粒细胞颗粒存在于嗜酸性疾病(包括哮喘)的组织中。这表明嗜酸性粒细胞裂解并释放细胞内容物，可能损害组织。

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Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho‐associated protein kinase signalling

The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Cell‐free eosinophil granules are found in tissues in eosinophilic diseases, including asthma. This suggests that eosinophils have lysed and released cellular content, likely harming tissues.

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Clinical & Experimental Allergy

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