磁性纳米颗粒射频电容式涂敷器的加热性能

Y. Iseki, Y. Shindo, K. Saito, Kazuo Kato
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引用次数: 1

摘要

本研究描述了带有磁性纳米颗粒的射频(RF)电容式涂敷器的温度特性。在诊所里,有两种最常用的加热装置。这些加热装置中的一种是电介质加热施加器,而另一种类型是感应加热施加器。电介质加热涂敷器的缺点之一是容易使脂肪层过热。此外,还附有冷却系统以减少过热。然而,过热仍然是电介质施加器最显著的缺点之一。相比之下,使用感应加热装置难以对深部肿瘤产生局部加热能量。为了克服这些问题,我们提出了一种将磁性纳米颗粒与射频电容应用器结合使用的方法。此外,通过使用我们的原型射频电容式应用器进行计算机模拟和加热实验,验证了所提出方法的有效性。本研究描述了与磁性纳米颗粒和热疗应用器的使用相关的温度特性。首先,介绍了介电加热装置和感应加热装置的特性。其次,在100 MHz ~ 1.0 GHz频率范围内测量了浓度为20 ~ 60 mg / cm3的磁性纳米颗粒的电性能,并利用有限元法计算了磁性纳米颗粒射频电容式涂敷器的温度特性。最后,利用原型射频电容式涂敷器和红外热像仪进行了加热实验。这些研究结果表明,在具有磁性纳米颗粒的射频电容式应用器中,介质加热是主要的加热机制。此外,有人认为磁性纳米颗粒的使用将使控制病人体内的加热区域成为可能。因此,我们观察到,基于计算机模拟和加热实验的结果,使用磁性纳米颗粒进行有效的热疗治疗是可能的。
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Heating Properties of RF Capacitive Applicator with Magnetic Nanoparticles
: This study describes the temperature properties of the radio frequency ( RF ) capacitive applicator with magnetic nanoparticles. In a clinic, two types of heating devices are most commonly used. One among these heating devices is a dielectric heating applicator, whereas the other type is an induction heating applicator. One of the disadvantages of dielectric heating applicators is their tendency to overheat the fat layers. Further, a cooling system is attached to reduce overheating. However, overheating remains one of most significant disadvantages of a dielectric applicator. In contrast, it is difficult to produce localized heating energy to the deep-seated tumors using induction heating applicators. To overcome these problems, we propose a method for using magnetic nanoparticles combined with an RF capacitive applicator. Further, the effectiveness of the proposed method has been examined by performing computer simulations and heating experiments using our prototype RF capacitive applicator. This study describes the temperature properties that are associated with the usage of magnetic nanoparticles and a hyperthermia applicator. First, the characteristics of a dielectric heating device and an induction heating device are described. Second, the electric properties of magnetic nanoparticles that exhibit concentrations ranging from 20 to 60 mg / cm 3 are measured in the frequency range from 100 MHz to 1.0 GHz, further, the temperature properties of the RF capacitive applicator with magnetic nanoparticles are calculated using the finite element method (FEM). Finally, the heating experiments are conducted using our prototype RF capacitive applicator and infrared thermal camera. These results of this study indicated that dielectric heating was the dominant heating mechanism in case of an RF capacitive applicator with magnetic nanoparticles. Additionally, it was suggested that the usage of magnetic nanoparticles will make it possible to control the heated area inside a patient ʼ s body. Thus, we observed that it was possible to use magnetic nanoparticles for performing effective hyperthermia treatment based on the results of both computer simulations and heating experiments.
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