Prabhudas Nelaturi, Sangeetha P Kademani, Vithiavathi Siva Subramanian, Sambandam Ravikumar
{"title":"酒精相关肝病的无创生物标志物--蛋白质组学相关初步报告","authors":"Prabhudas Nelaturi, Sangeetha P Kademani, Vithiavathi Siva Subramanian, Sambandam Ravikumar","doi":"10.1007/s12291-023-01120-9","DOIUrl":null,"url":null,"abstract":"<p><p>Increased alcohol intake over decades leads to progressive alcohol-related liver disease (ALD) and contributes to increased mortality. It is characterized by reduced platelet count. Platelets have a role in protecting vascular integrity and involved in liver regeneration. Alcohol affects the platelet count and its function. Platelet function is regulated by their proteins, released during pathophysiological conditions. Therefore, platelet proteome plays a vital role during ALD. This preliminary study consists of 10 patients with ALD. It includes the preparation of human platelets for the proteomic approach. We performed liquid chromatography-mass spectrometry for the samples. A total of 536 proteins were identified in patients with ALD of which 31 proteins were mentioned as a candidate based on their clinical significance. The advancement of diagnostic or therapeutic tools based on the application of platelet proteins in ALD is still far off. Platform for platelet and its proteome research may give diagnostic and prognostic insights into ALD. Platelet proteomes could possibly be concluded as therapeutic and potential diagnostic or prognostic markers in ALD.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-023-01120-9.</p>","PeriodicalId":48371,"journal":{"name":"Journal of Ethnic and Migration Studies","volume":"7 1","pages":"392-400"},"PeriodicalIF":2.8000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239637/pdf/","citationCount":"0","resultStr":"{\"title\":\"Noninvasive Biomarkers for Alcohol-Related Liver Disease-A Proteomic Related Preliminary Report.\",\"authors\":\"Prabhudas Nelaturi, Sangeetha P Kademani, Vithiavathi Siva Subramanian, Sambandam Ravikumar\",\"doi\":\"10.1007/s12291-023-01120-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Increased alcohol intake over decades leads to progressive alcohol-related liver disease (ALD) and contributes to increased mortality. It is characterized by reduced platelet count. Platelets have a role in protecting vascular integrity and involved in liver regeneration. Alcohol affects the platelet count and its function. Platelet function is regulated by their proteins, released during pathophysiological conditions. Therefore, platelet proteome plays a vital role during ALD. This preliminary study consists of 10 patients with ALD. It includes the preparation of human platelets for the proteomic approach. We performed liquid chromatography-mass spectrometry for the samples. A total of 536 proteins were identified in patients with ALD of which 31 proteins were mentioned as a candidate based on their clinical significance. The advancement of diagnostic or therapeutic tools based on the application of platelet proteins in ALD is still far off. Platform for platelet and its proteome research may give diagnostic and prognostic insights into ALD. Platelet proteomes could possibly be concluded as therapeutic and potential diagnostic or prognostic markers in ALD.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12291-023-01120-9.</p>\",\"PeriodicalId\":48371,\"journal\":{\"name\":\"Journal of Ethnic and Migration Studies\",\"volume\":\"7 1\",\"pages\":\"392-400\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239637/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Ethnic and Migration Studies\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12291-023-01120-9\",\"RegionNum\":1,\"RegionCategory\":\"社会学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/3/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"DEMOGRAPHY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ethnic and Migration Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12291-023-01120-9","RegionNum":1,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DEMOGRAPHY","Score":null,"Total":0}
Noninvasive Biomarkers for Alcohol-Related Liver Disease-A Proteomic Related Preliminary Report.
Increased alcohol intake over decades leads to progressive alcohol-related liver disease (ALD) and contributes to increased mortality. It is characterized by reduced platelet count. Platelets have a role in protecting vascular integrity and involved in liver regeneration. Alcohol affects the platelet count and its function. Platelet function is regulated by their proteins, released during pathophysiological conditions. Therefore, platelet proteome plays a vital role during ALD. This preliminary study consists of 10 patients with ALD. It includes the preparation of human platelets for the proteomic approach. We performed liquid chromatography-mass spectrometry for the samples. A total of 536 proteins were identified in patients with ALD of which 31 proteins were mentioned as a candidate based on their clinical significance. The advancement of diagnostic or therapeutic tools based on the application of platelet proteins in ALD is still far off. Platform for platelet and its proteome research may give diagnostic and prognostic insights into ALD. Platelet proteomes could possibly be concluded as therapeutic and potential diagnostic or prognostic markers in ALD.
Supplementary information: The online version contains supplementary material available at 10.1007/s12291-023-01120-9.
期刊介绍：
The Journal of Ethnic and Migration Studies (JEMS) publishes the results of first-class research on all forms of migration and its consequences, together with articles on ethnic conflict, discrimination, racism, nationalism, citizenship and policies of integration. Contributions to the journal, which are all fully refereed, are especially welcome when they are the result of original empirical research that makes a clear contribution to the field of migration JEMS has a long-standing interest in informed policy debate and contributions are welcomed which seek to develop the implications of research for policy innovation, or which evaluate the results of previous initiatives. The journal is also interested in publishing the results of theoretical work.
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