人脐带血间充质干细胞可改善高位胫骨截骨术后的临床疗效和关节间隙宽度。

D. Suh, Seung-Beom Han, W. Yeo, Kuhoang Cheong, Sang-Yeon So, B. Kyung
{"title":"人脐带血间充质干细胞可改善高位胫骨截骨术后的临床疗效和关节间隙宽度。","authors":"D. Suh, Seung-Beom Han, W. Yeo, Kuhoang Cheong, Sang-Yeon So, B. Kyung","doi":"10.21203/RS.3.RS-257427/V1","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nThere is limited study about the human umbilical cord-blood derived mesenchymal stem cell (hUCB-MSC) cartilage regeneration procedures combined with high tibial osteotomy (HTO). We compared the clinical and radiological results of hUCB-MSC cartilage regeneration procedures combined with HTO to those of microfracture with HTO.\n\n\nMETHODS\nFrom August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm2 on medial femoral condyle (MFC) were enrolled. For comparison, all participants were divided into two groups: those who had undergone an hUCB-MSC induced cartilage regeneration procedure (group MSC) and those with microfractures only (group C, controls). Clinically, Hospital for Special Surgery (HSS), International Knee Documentation Committee (IKDC), and Lysholm scores were evaluated post-operatively at 18 months. Radiologically, mechanical axis (MA) and joint space width (JSW) were evaluated.\n\n\nRESULTS\nA total of 100 knees were enrolled (43 in group MSC, 57 in group C). The IKDC score in group MSC (69) was better than that in group C (62; P < 0.05). The JSW increment in the MSC group (0.6 mm) was more than that in group C (0.1 mm; P < 0.05). No patient developed nonunion, correction loss, or arthroplasty conversion.\n\n\nCONCLUSION\nhUCB-MSCs can improve clinical outcome and JSW better than microfracture only in HTO patients.","PeriodicalId":22205,"journal":{"name":"The American journal of knee surgery","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Human umbilical cord-blood-derived mesenchymal stem cell can improve the clinical outcome and Joint space width after high tibial osteotomy.\",\"authors\":\"D. Suh, Seung-Beom Han, W. Yeo, Kuhoang Cheong, Sang-Yeon So, B. Kyung\",\"doi\":\"10.21203/RS.3.RS-257427/V1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\nThere is limited study about the human umbilical cord-blood derived mesenchymal stem cell (hUCB-MSC) cartilage regeneration procedures combined with high tibial osteotomy (HTO). We compared the clinical and radiological results of hUCB-MSC cartilage regeneration procedures combined with HTO to those of microfracture with HTO.\\n\\n\\nMETHODS\\nFrom August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm2 on medial femoral condyle (MFC) were enrolled. For comparison, all participants were divided into two groups: those who had undergone an hUCB-MSC induced cartilage regeneration procedure (group MSC) and those with microfractures only (group C, controls). Clinically, Hospital for Special Surgery (HSS), International Knee Documentation Committee (IKDC), and Lysholm scores were evaluated post-operatively at 18 months. Radiologically, mechanical axis (MA) and joint space width (JSW) were evaluated.\\n\\n\\nRESULTS\\nA total of 100 knees were enrolled (43 in group MSC, 57 in group C). The IKDC score in group MSC (69) was better than that in group C (62; P < 0.05). The JSW increment in the MSC group (0.6 mm) was more than that in group C (0.1 mm; P < 0.05). No patient developed nonunion, correction loss, or arthroplasty conversion.\\n\\n\\nCONCLUSION\\nhUCB-MSCs can improve clinical outcome and JSW better than microfracture only in HTO patients.\",\"PeriodicalId\":22205,\"journal\":{\"name\":\"The American journal of knee surgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The American journal of knee surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21203/RS.3.RS-257427/V1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American journal of knee surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21203/RS.3.RS-257427/V1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

摘要

关于人脐带血源性间充质干细胞(hUCB-MSC)软骨再生手术联合胫骨高位截骨术(HTO)的研究有限。我们比较了hub - msc软骨再生联合HTO与微骨折联合HTO的临床和影像学结果。方法2017年8月至2018年12月,纳入国际软骨再生与关节保存学会(ICRS)评定的股骨内侧髁(MFC)软骨缺损超过200 mm2的HTO患者。为了进行比较,所有参与者分为两组:接受hub -MSC诱导的软骨再生手术(MSC组)和仅微骨折(C组,对照组)。临床采用特殊外科医院(HSS)、国际膝关节文献委员会(IKDC)和Lysholm评分于术后18个月进行评估。影像学上评估机械轴(MA)和关节间隙宽度(JSW)。结果共入组膝关节100例(MSC组43例,C组57例),MSC组IKDC评分(69分)优于C组(62分);p < 0.05)。MSC组JSW增加量(0.6 mm)大于C组(0.1 mm);p < 0.05)。没有患者出现骨不连、矫正丢失或关节置换。结论hub - mscs对HTO患者的临床疗效和JSW的改善效果优于单纯的微骨折。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Human umbilical cord-blood-derived mesenchymal stem cell can improve the clinical outcome and Joint space width after high tibial osteotomy.
BACKGROUND There is limited study about the human umbilical cord-blood derived mesenchymal stem cell (hUCB-MSC) cartilage regeneration procedures combined with high tibial osteotomy (HTO). We compared the clinical and radiological results of hUCB-MSC cartilage regeneration procedures combined with HTO to those of microfracture with HTO. METHODS From August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm2 on medial femoral condyle (MFC) were enrolled. For comparison, all participants were divided into two groups: those who had undergone an hUCB-MSC induced cartilage regeneration procedure (group MSC) and those with microfractures only (group C, controls). Clinically, Hospital for Special Surgery (HSS), International Knee Documentation Committee (IKDC), and Lysholm scores were evaluated post-operatively at 18 months. Radiologically, mechanical axis (MA) and joint space width (JSW) were evaluated. RESULTS A total of 100 knees were enrolled (43 in group MSC, 57 in group C). The IKDC score in group MSC (69) was better than that in group C (62; P < 0.05). The JSW increment in the MSC group (0.6 mm) was more than that in group C (0.1 mm; P < 0.05). No patient developed nonunion, correction loss, or arthroplasty conversion. CONCLUSION hUCB-MSCs can improve clinical outcome and JSW better than microfracture only in HTO patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Kinematic comparison between the knee after bicruciate stabilized total knee arthroplasty and the native knee: A cadaveric study. Is cement mantle thickness a primary cause of aseptic tibial loosening following primary total knee arthroplasty? A new look at quadriceps tendon - Is it really composed of three layers? An analysis of the incidence, risk factors, and timing of development of cyclops lesions after anterior cruciate ligament reconstruction. Immunohistochemical analysis of the quadriceps femoris muscle before and after total knee arthroplasty.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1