An efficient one-pot, four-component synthesis of a series of pyrazolo [3,4-b] pyridines in the presence of magnetic LDH as a nanocatalyst

In this research study, one-pot, four-component reaction of 3-aryl-3-oxopropanenitriles, 1-aryl-3-methyl-1H-pyrazol-5 (4H) one, arylglyoxals and ammonium acetate using green solvent systems and different catalysts under the reflux conditions afforded a series of the corresponding 4-aroyl-3-methyl-1,6-diaryl-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile derivatives. The best yields (70-85%) were obtained using the metal oxide silica based-matal bifunctional LDH (layered double hydroxide) as a magnet nanocatalyst in EtOH/H2O (1:1) under the reflux conditions. This protocol provided mild reaction conditions, good yields, simple workup procedure, easy preparation of nanocatalyst and, products to structurally diverse bicyclic pyrazolo [3,4-b] pyridines, demonstrating biological and pharmacological activities.