{"title":"基于非负矩阵分解的统一多视图聚类方法用于癌症亚型分型","authors":"Zhanpeng Huang, Jiekang Wu, Jinlin Wang, Yu Lin, Xiaohua Chen","doi":"10.4018/ijdwm.319956","DOIUrl":null,"url":null,"abstract":"Non-negative matrix factorization (NMF) has gained sustaining attention due to its compact leaning ability. Cancer subtyping is important for cancer prognosis analysis and clinical precision treatment. Integrating multi-omics data for cancer subtyping is beneficial to uncover the characteristics of cancer at the system-level. A unified multi-view clustering method was developed via adaptive graph and sparsity regularized non-negative matrix factorization (multi-GSNMF) for cancer subtyping. The local geometrical structures of each omics data were incorporated into the procedures of common consensus matrix learning, and the sparsity constraints were used to reduce the effect of noise and outliers in bioinformatics datasets. The performances of multi-GSNMF were evaluated on ten cancer datasets. Compared with 10 state-of-the-art multi-view clustering algorithms, multi-GSNMF performed better by providing significantly different survival in 7 out of 10 cancer datasets, the highest among all the compared methods.","PeriodicalId":54963,"journal":{"name":"International Journal of Data Warehousing and Mining","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A Unified Multi-View Clustering Method Based on Non-Negative Matrix Factorization for Cancer Subtyping\",\"authors\":\"Zhanpeng Huang, Jiekang Wu, Jinlin Wang, Yu Lin, Xiaohua Chen\",\"doi\":\"10.4018/ijdwm.319956\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Non-negative matrix factorization (NMF) has gained sustaining attention due to its compact leaning ability. Cancer subtyping is important for cancer prognosis analysis and clinical precision treatment. Integrating multi-omics data for cancer subtyping is beneficial to uncover the characteristics of cancer at the system-level. A unified multi-view clustering method was developed via adaptive graph and sparsity regularized non-negative matrix factorization (multi-GSNMF) for cancer subtyping. The local geometrical structures of each omics data were incorporated into the procedures of common consensus matrix learning, and the sparsity constraints were used to reduce the effect of noise and outliers in bioinformatics datasets. The performances of multi-GSNMF were evaluated on ten cancer datasets. Compared with 10 state-of-the-art multi-view clustering algorithms, multi-GSNMF performed better by providing significantly different survival in 7 out of 10 cancer datasets, the highest among all the compared methods.\",\"PeriodicalId\":54963,\"journal\":{\"name\":\"International Journal of Data Warehousing and Mining\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Data Warehousing and Mining\",\"FirstCategoryId\":\"94\",\"ListUrlMain\":\"https://doi.org/10.4018/ijdwm.319956\",\"RegionNum\":4,\"RegionCategory\":\"计算机科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"COMPUTER SCIENCE, SOFTWARE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Data Warehousing and Mining","FirstCategoryId":"94","ListUrlMain":"https://doi.org/10.4018/ijdwm.319956","RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"COMPUTER SCIENCE, SOFTWARE ENGINEERING","Score":null,"Total":0}
A Unified Multi-View Clustering Method Based on Non-Negative Matrix Factorization for Cancer Subtyping
Non-negative matrix factorization (NMF) has gained sustaining attention due to its compact leaning ability. Cancer subtyping is important for cancer prognosis analysis and clinical precision treatment. Integrating multi-omics data for cancer subtyping is beneficial to uncover the characteristics of cancer at the system-level. A unified multi-view clustering method was developed via adaptive graph and sparsity regularized non-negative matrix factorization (multi-GSNMF) for cancer subtyping. The local geometrical structures of each omics data were incorporated into the procedures of common consensus matrix learning, and the sparsity constraints were used to reduce the effect of noise and outliers in bioinformatics datasets. The performances of multi-GSNMF were evaluated on ten cancer datasets. Compared with 10 state-of-the-art multi-view clustering algorithms, multi-GSNMF performed better by providing significantly different survival in 7 out of 10 cancer datasets, the highest among all the compared methods.
期刊介绍:
The International Journal of Data Warehousing and Mining (IJDWM) disseminates the latest international research findings in the areas of data management and analyzation. IJDWM provides a forum for state-of-the-art developments and research, as well as current innovative activities focusing on the integration between the fields of data warehousing and data mining. Emphasizing applicability to real world problems, this journal meets the needs of both academic researchers and practicing IT professionals.The journal is devoted to the publications of high quality papers on theoretical developments and practical applications in data warehousing and data mining. Original research papers, state-of-the-art reviews, and technical notes are invited for publications. The journal accepts paper submission of any work relevant to data warehousing and data mining. Special attention will be given to papers focusing on mining of data from data warehouses; integration of databases, data warehousing, and data mining; and holistic approaches to mining and archiving