{"title":"在伽玛辐射或法莫柔比星(48-环氧多柔比星)治疗后，心氧环(icrf-187, dexrazoxane)不能限制大鼠的过氧化性心脏损伤","authors":"W. Przybyszewski, M. Wideł","doi":"10.1080/107691897229694","DOIUrl":null,"url":null,"abstract":"The ability of Cardioxane to protect against the peroxidative type of heart damage induced by a single treatm ent with farmorubicin (10 mg/ kg ip) or ionizing radiation (20 Gy gam ma rays) as well was investigated in WAG strain rats. Cardioxane in doses 20 mg/ kg was applied ip 1 h before and 20 h after farmorubicin treatment or 30 m in before and 20 h after irradiation. The early markers of peroxidative damage were thiobarbituric acid-reactive substances (TBA-RS) in serum and heart homogenate, and the cytoplasm ic enzyme creatine kinase CK (CPK) activity in serum. Results indicate that Cardioxane in clinically relevant doses did not exert a protective effect against oxidative reactions and did not significantly influence the changes of serum enzym e level observed after both cardiotoxic agents. Furthermore, Cardioxane alone induced a sm all but significant increase of TBA-RS in serum and heart tissue, providing additional toxicity.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"FAILURE OF CARDIOXANE (ICRF-187, DEXRAZOXANE) TO LIMIT PEROXIDATIVE HEART DAMAGE IN RATS AFTER GAMMA IRRADIATION OR FARMORUBICIN (48-EPIDOXORUBICIN) TREATMENT\",\"authors\":\"W. Przybyszewski, M. Wideł\",\"doi\":\"10.1080/107691897229694\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The ability of Cardioxane to protect against the peroxidative type of heart damage induced by a single treatm ent with farmorubicin (10 mg/ kg ip) or ionizing radiation (20 Gy gam ma rays) as well was investigated in WAG strain rats. Cardioxane in doses 20 mg/ kg was applied ip 1 h before and 20 h after farmorubicin treatment or 30 m in before and 20 h after irradiation. The early markers of peroxidative damage were thiobarbituric acid-reactive substances (TBA-RS) in serum and heart homogenate, and the cytoplasm ic enzyme creatine kinase CK (CPK) activity in serum. Results indicate that Cardioxane in clinically relevant doses did not exert a protective effect against oxidative reactions and did not significantly influence the changes of serum enzym e level observed after both cardiotoxic agents. Furthermore, Cardioxane alone induced a sm all but significant increase of TBA-RS in serum and heart tissue, providing additional toxicity.\",\"PeriodicalId\":87425,\"journal\":{\"name\":\"Toxic substance mechanisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxic substance mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/107691897229694\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/107691897229694","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
FAILURE OF CARDIOXANE (ICRF-187, DEXRAZOXANE) TO LIMIT PEROXIDATIVE HEART DAMAGE IN RATS AFTER GAMMA IRRADIATION OR FARMORUBICIN (48-EPIDOXORUBICIN) TREATMENT
The ability of Cardioxane to protect against the peroxidative type of heart damage induced by a single treatm ent with farmorubicin (10 mg/ kg ip) or ionizing radiation (20 Gy gam ma rays) as well was investigated in WAG strain rats. Cardioxane in doses 20 mg/ kg was applied ip 1 h before and 20 h after farmorubicin treatment or 30 m in before and 20 h after irradiation. The early markers of peroxidative damage were thiobarbituric acid-reactive substances (TBA-RS) in serum and heart homogenate, and the cytoplasm ic enzyme creatine kinase CK (CPK) activity in serum. Results indicate that Cardioxane in clinically relevant doses did not exert a protective effect against oxidative reactions and did not significantly influence the changes of serum enzym e level observed after both cardiotoxic agents. Furthermore, Cardioxane alone induced a sm all but significant increase of TBA-RS in serum and heart tissue, providing additional toxicity.
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