尼日利亚阿布贾阿布贾大学教学医院肾病综合征儿童急性肾损伤:2016年至2021年

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL AIMS Medical Science Pub Date : 2022-01-01 DOI:10.3934/medsci.2022004
E. Anigilaje, Ishola Ibraheem
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引用次数: 1

摘要

背景:尼日利亚儿童肾病综合征(NS)中关于急性肾损伤(AKI)的信息很少。本研究描述了尼日利亚阿布贾阿布贾大学教学医院(UATH) NS患儿AKI的患病率、危险因素和结局。材料和方法这是一项对2016年1月至2021年10月在UATH患有NS的儿童的综述。AKI按照儿科RIFLE标准进行分类。结果75例NS患儿,年龄13个月~ 18岁,平均年龄(10±18岁),男性居多(64例,85.3%)。75名受试者中有19人(25.3%)发生AKI,其中15人失败(78.9%),3人受伤(15.8%),1人有风险(5.3%)。住院时AKI危险因素探讨无脓毒症的受试者发生AKI的几率降低(OR = 0.01, 95% CI = 0.02-0.06, p < 0.001);无明显血尿的受试者发生AKI的风险降低(OR = 0.07, 95% CI = 0.01-0.66, p = 0.004)。存在腹膜炎(OR = 7.91, 95% CI = 2.15-29.15, p < 0.001)和尿路感染(OR = 2.55, 95% CI = 1.39-4.66, p < 0.001)时AKI的可能性增加。既往暴露于肾毒性药物(NTM)的受试者也有AKI的风险(OR = 1.79, 95% CI = 1.13-2.84, p = 0.001)。短期内观察到的仅有2例死亡(2.6%)是AKI患者(2/ 19,10.5%),但大多数患者肾脏完全恢复(16/ 19,84.2%)。结论aki在NS患儿中较为常见。脓毒症、肉眼血尿、腹膜炎、尿路感染和NTM是其确定的危险因素。在我们的环境中,有这些危险因素的NS患儿有AKI的怀疑是谨慎的。
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Acute kidney injury in children with nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: 2016 to 2021
Background Information regarding acute kidney injury (AKI) is scarce among Nigerian children with nephrotic syndrome (NS). This study describes the prevalence, risk factors and outcomes of AKI among children with NS at the University of Abuja Teaching Hospital (UATH), Abuja, Nigeria. Materials and methods This is a review of children with NS, from January 2016 to October 2021 at the UATH. AKI was classified by the paediatric RIFLE criteria. Results Of the 75 children with NS, aged 13 months to 18 years, with a mean age of 10 ± 18 years, and majorly (64, 85.3%) males. AKI occurred in 19 of 75 (25.3%) subjects comprising Failure in 15 (78.9%), Injury in 3 (15.8%) and Risk in 1 (5.3%). Regarding risk factors of AKI at hospital admission; subjects with no sepsis were at reduced odds of AKI (OR = 0.01, 95% CI = 0.02–0.06, p < 0.001); and the risk of AKI was reduced among subjects without gross haematuria (OR = 0.07, 95% CI = 0.01–0.66, p = 0.004). The likelihood of AKI increased in the presence of peritonitis (OR = 7.91, 95% CI = 2.15–29.15, p < 0.001) and urinary tract infections (UTIs) (OR = 2.55, 95% CI = 1.39–4.66, p < 0.001). Subjects with historical exposure to nephrotoxic medications (NTM) were also at risk of AKI (OR = 1.79, 95% CI = 1.13–2.84, p = 0.001). The only 2 deaths (2.6%) observed in the short term was among those with AKI (2/19, 10.5%) but full renal recovery occurred in the majority (16/19, 84.2%). Conclusions AKI is common in our children with NS. Sepsis, gross haematuria, peritonitis, UTIs and NTM were its identified risk factors. It is prudent to have a suspicion of AKI among children with NS with these risk factors in our setting.
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来源期刊
AIMS Medical Science
AIMS Medical Science MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
14.30%
发文量
20
审稿时长
12 weeks
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