神经激肽-1受体:一个有前途的抗肿瘤靶点

R. Coveñas, F. D. Rodríguez, M. Muñoz
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引用次数: 4

摘要

本文综述了P物质(SP)/神经动素-1受体(NK-1R)系统在肿瘤中的重要作用,包括肿瘤细胞的增殖和迁移、抗凋亡机制和血管生成。SP通过NK-1R在癌细胞中作为一种通用的丝裂原发挥作用。NK-1R在肿瘤细胞中过表达,并影响癌细胞的生存能力。NK-1R拮抗剂通过NK-1R抵消SP介导的所有上述作用。这些拮抗剂以浓度依赖性的方式通过细胞凋亡促进肿瘤细胞死亡。因此,通过单独使用NK-1R拮抗剂(如阿瑞吡坦)或与化疗或放疗联合治疗,NK-1R是一个潜在且有前景的癌症治疗靶点。
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The Neurokinin-1 Receptor: A Promising Antitumor Target
The important role played by the substance P (SP)/neurokinin-1 receptor (NK-1R) system in cancer is reviewed: this includes tumor cell proliferation and migration, anti-apoptotic mechanisms, and angiogenesis. SP, through the NK-1R, behaves as a universal mitogen in cancer cells. The NK-1R is overexpressed in tumor cells and, in addition, affects the viability of cancer cells. NK-1R antagonists counteract all the previous actions mediated by SP through NK-1R. In a concentration-dependent manner, these antagonists promote tumor cell death by apoptosis. Therefore, NK-1R is a potential and promising therapeutic target for cancer treatment by using NK-1R antagonists (e.g., aprepitant) alone or in combination therapy with chemotherapy or radiotherapy.
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