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引用次数: 0
摘要
前庭性偏头痛(Vestibular migraine,VM)是指由偏头痛机制引起的前庭症状。由于在半规管和耳石器官同时受到刺激时(如相对于重力倾斜头部),偏头痛患者经常会感到头晕,因此我们测量了偏头痛患者以及偏头痛和正常对照受试者在固定半径离心过程中的倾斜感知和眼球运动。24 名患者(每类 8 人)接受了运动范式测试,该范式会产生 0.36 G 的耳际离心力,导致重力惯性力在滚动平面上倾斜 20°。我们发现,与两个对照组相比,VM 患者对滚动倾斜的感知发展较慢,但三组患者的眼球运动反应(包括眼球旋转轴的移动)是相同的。这些结果表明,VM 患者的前庭知觉发生了变化,但前庭介导的眼球运动并没有随之发生变化,这表明 VM 患者的大脑对耳道和耳石信号的整合或耳石反应的动态发生了异常。
Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine.
Vestibular migraine (VM), defined as vestibular symptoms caused by migraine mechanisms, is very common but poorly understood. Because dizziness is often provoked in VM patients when the semicircular canals and otolith organs are stimulated concurrently (e.g., tilting the head relative to gravity), we measured tilt perception and eye movements in patients with VM and in migraine and normal control subjects during fixed-radius centrifugation, a paradigm that simultaneously modulates afferent signals from the semicircular canals and otoliths organs. Twenty-four patients (8 in each category) were tested with a motion paradigm that generated an inter-aural centrifugal force of 0.36 G, resulting in a 20° tilt of the gravito-inertial force in the roll plane. We found that percepts of roll tilt developed slower in VM patients than in the two control groups, but that eye movement responses, including the shift in the eye's rotational axis, were equivalent in all three groups. These results demonstrate a change in vestibular perception in VM that is unaccompanied by changes in vestibular-mediated eye movements and suggest that either the brain's integration of canal and otolith signals or the dynamics of otolith responses are aberrant in patients with VM.