Na Mukungu, K. Abuga, N. Mungai, K. Bosire, E. Karumi
{"title":"烟灰andra physaloides非生物碱提取物中化合物的分离、结构分析及withanicandrin的抑菌活性","authors":"Na Mukungu, K. Abuga, N. Mungai, K. Bosire, E. Karumi","doi":"10.4314/ECAJPS.V16I2","DOIUrl":null,"url":null,"abstract":"The aerial parts of Nicandra physaloides plant collected from Kenyatta National Hospital grounds were dried and subjected to acid-base extraction and partitioned to obtain alkaloidal and non-alkaloidal extracts. The non-alkaloidal extract yielded three compounds; withanicandrin, â-sitosterol and stigmasterol after column chromatography. Withanicandrin exhibited antifungal activity against Saccharomyces cerevisiae and Candida albicans but lacked antibacterial activity. Key words: Nicandra physaloides , withanicandrin, β-sitosterol, stigmasterol, antifungal activity.","PeriodicalId":22387,"journal":{"name":"The East and Central African Journal of Pharmaceutical Sciences","volume":"1 1","pages":"49-53"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin\",\"authors\":\"Na Mukungu, K. Abuga, N. Mungai, K. Bosire, E. Karumi\",\"doi\":\"10.4314/ECAJPS.V16I2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aerial parts of Nicandra physaloides plant collected from Kenyatta National Hospital grounds were dried and subjected to acid-base extraction and partitioned to obtain alkaloidal and non-alkaloidal extracts. The non-alkaloidal extract yielded three compounds; withanicandrin, â-sitosterol and stigmasterol after column chromatography. Withanicandrin exhibited antifungal activity against Saccharomyces cerevisiae and Candida albicans but lacked antibacterial activity. Key words: Nicandra physaloides , withanicandrin, β-sitosterol, stigmasterol, antifungal activity.\",\"PeriodicalId\":22387,\"journal\":{\"name\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"volume\":\"1 1\",\"pages\":\"49-53\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The East and Central African Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ECAJPS.V16I2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The East and Central African Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ECAJPS.V16I2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin
The aerial parts of Nicandra physaloides plant collected from Kenyatta National Hospital grounds were dried and subjected to acid-base extraction and partitioned to obtain alkaloidal and non-alkaloidal extracts. The non-alkaloidal extract yielded three compounds; withanicandrin, â-sitosterol and stigmasterol after column chromatography. Withanicandrin exhibited antifungal activity against Saccharomyces cerevisiae and Candida albicans but lacked antibacterial activity. Key words: Nicandra physaloides , withanicandrin, β-sitosterol, stigmasterol, antifungal activity.
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