Raymond M. Wang , Jingjin He , Yang Xu , Karen L. Christman
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Humanized mouse model for evaluating biocompatibility and human immune cell interactions to biomaterials
Immune system humanized mice provide unique platforms for improving preclinical evaluation of the human immune response to novel biomaterial therapies. Wild-type animals and human immune cell in vitro cultures provide limited representation of the human immune response, leading to unexpected responses to therapies in human patients. Introducing human tissue, cells, and genes into immunodeficient mice have advanced these animal models to reconstitute multiple lineages of functional and maturely differentiated human immune cell populations. Safe implantation and remodeling responses promoting stable tissue resolutions are critical parameters coordinated by the immune response, which should be evaluated for new biomaterial therapeutics. This review discusses the development of immune system humanized mice, and highlights demonstrated use in biomaterial and related human immune response studies.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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