De‐labelling of beta‐lactam allergy in children

Allergic reactions to betalactam antibiotics, specifically aminopenicillin, are the most common cause of adverse drug reactions reported in children and adults.1 A substantial number of children treated with betalactams (BLs) develop delayed maculopapular exanthema or urticaria, and the most frequent aetiology for these symptoms is either infectious or unknown. Ruling out drug allergy is always advisable as these mild clinical presentations have proven to be poor predictors of true allergy.2 Although these conditions are among the most frequent causes of allergy referral, their management is still controversial.