Hongdai Sun, Yawei Wang, Xue-Jin Huang, Yuanwen Zou
{"title":"膜顺应腔提高体外模拟加速环境下人体循环系统的实验研究","authors":"Hongdai Sun, Yawei Wang, Xue-Jin Huang, Yuanwen Zou","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.004","DOIUrl":null,"url":null,"abstract":"Objective \nTo improve the vitro simulation of the human circulation system under acceleration environment by studying a membrane compliance cavity. \n \n \nMethods \nThe vitro simulation of the human circulation system equipped with a membrane cavity wherein the air and liquid was separated by a silicone membrane (0.2 mm or 0.4 mm thick) in order to prevent the gas got into the system as soon as the simulated acceleration caused air-liquid interface tilt. The segmentation of air-liquid interface and deformation of silicone membranes were recorded by a high definition camera when 20 to 200 mmHg pressure applied to the cavity to simulate the acceleration effect. The compliance values at different pressures were calculated. \n \n \nResults \n①No air was found in the closed liquid loop when cavity was pressured. The deformation of 0.2 mm membrane was larger than that of 0.4 mm membrane. ②The membrane compliance cavity showed viscoelasticity feature both in pressure loading and unloading processes. When the cyclic loading was up to 3 times the loading curve of 0.2 mm membrane compliance cavity was almost overlapped on its unloading curve, but they did not coincide for the 0.4 mm membrane. ③The simulation range of 0.2 mm silicone membrane was in 0-1.4 ml/mmHg under 20-200 mmHg test pressures, while 0-0.4 ml/mmHg for 0.4 mm silicone membrane. \n \n \nConclusions \nThe membrane compliance cavity has solved the problem of the air-liquid interface segmentation under the simulated acceleration environment. The simulation range of compliance meets the needs of the vitro simulation for human circulatory system. \n \n \nKey words: \nAcceleration physiology; Blood circulatory; Compliance; In vitro simulation; Silica membrane cavity; Pilots","PeriodicalId":9904,"journal":{"name":"中华航空航天医学杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Experimental study of a membrane compliance cavity to improve vitro simulation of the human circulation system under acceleration environment\",\"authors\":\"Hongdai Sun, Yawei Wang, Xue-Jin Huang, Yuanwen Zou\",\"doi\":\"10.3760/CMA.J.ISSN.1007-6239.2018.02.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo improve the vitro simulation of the human circulation system under acceleration environment by studying a membrane compliance cavity. \\n \\n \\nMethods \\nThe vitro simulation of the human circulation system equipped with a membrane cavity wherein the air and liquid was separated by a silicone membrane (0.2 mm or 0.4 mm thick) in order to prevent the gas got into the system as soon as the simulated acceleration caused air-liquid interface tilt. The segmentation of air-liquid interface and deformation of silicone membranes were recorded by a high definition camera when 20 to 200 mmHg pressure applied to the cavity to simulate the acceleration effect. The compliance values at different pressures were calculated. \\n \\n \\nResults \\n①No air was found in the closed liquid loop when cavity was pressured. The deformation of 0.2 mm membrane was larger than that of 0.4 mm membrane. ②The membrane compliance cavity showed viscoelasticity feature both in pressure loading and unloading processes. When the cyclic loading was up to 3 times the loading curve of 0.2 mm membrane compliance cavity was almost overlapped on its unloading curve, but they did not coincide for the 0.4 mm membrane. ③The simulation range of 0.2 mm silicone membrane was in 0-1.4 ml/mmHg under 20-200 mmHg test pressures, while 0-0.4 ml/mmHg for 0.4 mm silicone membrane. \\n \\n \\nConclusions \\nThe membrane compliance cavity has solved the problem of the air-liquid interface segmentation under the simulated acceleration environment. The simulation range of compliance meets the needs of the vitro simulation for human circulatory system. \\n \\n \\nKey words: \\nAcceleration physiology; Blood circulatory; Compliance; In vitro simulation; Silica membrane cavity; Pilots\",\"PeriodicalId\":9904,\"journal\":{\"name\":\"中华航空航天医学杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华航空航天医学杂志\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华航空航天医学杂志","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Experimental study of a membrane compliance cavity to improve vitro simulation of the human circulation system under acceleration environment
Objective
To improve the vitro simulation of the human circulation system under acceleration environment by studying a membrane compliance cavity.
Methods
The vitro simulation of the human circulation system equipped with a membrane cavity wherein the air and liquid was separated by a silicone membrane (0.2 mm or 0.4 mm thick) in order to prevent the gas got into the system as soon as the simulated acceleration caused air-liquid interface tilt. The segmentation of air-liquid interface and deformation of silicone membranes were recorded by a high definition camera when 20 to 200 mmHg pressure applied to the cavity to simulate the acceleration effect. The compliance values at different pressures were calculated.
Results
①No air was found in the closed liquid loop when cavity was pressured. The deformation of 0.2 mm membrane was larger than that of 0.4 mm membrane. ②The membrane compliance cavity showed viscoelasticity feature both in pressure loading and unloading processes. When the cyclic loading was up to 3 times the loading curve of 0.2 mm membrane compliance cavity was almost overlapped on its unloading curve, but they did not coincide for the 0.4 mm membrane. ③The simulation range of 0.2 mm silicone membrane was in 0-1.4 ml/mmHg under 20-200 mmHg test pressures, while 0-0.4 ml/mmHg for 0.4 mm silicone membrane.
Conclusions
The membrane compliance cavity has solved the problem of the air-liquid interface segmentation under the simulated acceleration environment. The simulation range of compliance meets the needs of the vitro simulation for human circulatory system.
Key words:
Acceleration physiology; Blood circulatory; Compliance; In vitro simulation; Silica membrane cavity; Pilots
期刊介绍:
The aim of Chinese Journal of Aerospace Medicine is to combine theory and practice, improve and popularize, actively advocate a hundred flowers bloom and a hundred schools of thought contend, advocate seeking truth from facts, promote the development of the related disciplines of aerospace medicine and human efficiency, and promote the exchange and penetration of aerospace medicine and human efficiency with other biomedical and engineering specialties.
Topics of interest for Chinese Journal of Aerospace Medicine include:
-The content of the journal belongs to the discipline of special medicine and military medicine, with the characteristics of multidisciplinary synthesis and cross-penetration, and mainly reflected in the aerospace industry, aerospace flight safety and efficiency, as well as the synthesis of special medicine, preventive medicine, environmental medicine, psychology, etc.
-Military aeromedicine (Air Force, Navy and Army aeromedicine) and civil aeromedicine, with a balance of aerospace medicine are the strengths of the journal.
-The change in aerospace medicine from a focus on promoting physiological compensatory adaptations to enhancing human performance under extreme environmental conditions is what the journal is helping to promote.
-The expansion of manuscripts in high altitude medicine is also a special emphasis of the journal.