回复R. Härtl的评论:

M. Arts, W. Peul
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引用次数: 0

摘要

艺术MP等。管状椎间盘切除术与传统显微椎间盘切除术…微创神经外科2010;53:96管状椎间盘切除术并不优于常规手术,这并不是因为外科医生缺乏经验,H ä rtl及其同事认为。外科医生在参与我们的试验之前至少需要进行15次手术。此外,我们发现经验丰富的外科医生的结果往往更差。我们强烈反对将复发性椎间盘突出患者排除在初步分析之外的建议。首先,在意向治疗分析中,根据定义,主要终点应包括所有可能导致不良结果的患者。此外,复发性椎间盘突出很可能是组间疼痛评分差异的重要原因。决定新的指导方针,两组的最终临床结果,包括其所有决定因素,是至关重要的。在我们看来,排除这些患者肯定会使主要结果产生偏差。我们同意“管状椎间盘切除术与传统手术相比缺乏益处并不意味着管状椎间盘切除术在与r.h ä rtl的评论相比可能更具侵入性时没有显著优势”的说法。
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Reply to the comment of R. Härtl:
Arts MP et al. Tubular Discectomy vs. Conventional Microdiscectomy ... Minim Invas Neurosurg 2010; 53: 96 The fact that tubular discectomy was not superior to conventional surgery was not due to inexperience of surgeons, as H ä rtl and colleagues suggest. Surgeons needed to perform at least 15 procedures before they could participate in our trial [1] . Moreover, we found a tendency of worse results in more experienced surgeons. We strongly disagree with the suggestion to exclude the patients with recurrent disk herniation from primary analysis. First, in an intention-to-treat analysis, by defi nition, the primary endpoint should include all patients with all possible reasons for an unfavourable outcome. Moreover, recurrent disk herniation might very well be an important reason for diff erence in pain scores between the groups. To decide on new guidelines, the fi nal clinical result of both groups, including all its determinants, is crucial. In our opinion, excluding these patients would certainly bias the primary outcome. We agree with the statement that ‘ the lack of benefi t from tubular discectomy over conventional surgery does not mean that tubular surgery would not have a signifi cant advantage when comparing potentially much more invasive proceReply to the comment of R. H ä rtl:
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来源期刊
Minimally Invasive Neurosurgery
Minimally Invasive Neurosurgery 医学-临床神经学
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>12 weeks
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