免疫能力患者的脓毒性多关节炎和坏死性筋膜炎。个案报告

Carlos A. Sánchez , Daniela Sierra , Luisa F. García , Amparo Gómez
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引用次数: 0

摘要

脓毒性多发性关节炎在免疫功能正常的患者中是非常罕见的,当它与化脓性链球菌(SP)引起的坏死性筋膜炎共存时更是如此。一个54岁,免疫功能正常的男性病人在这里提出。在安装感染性关节炎之前,患者没有相关的疾病,他的双膝和左脚踝。患者接受顺序手术清创治疗,随后出现左腿后侧坏死性筋膜炎,需要适当治疗(包括真空辅助缝合),并对特定感染微生物(青霉素+万古霉素)进行抗生素治疗。然而,经过一个月的外科治疗,包括整形外科、皮肤科、骨科以及重症监护病房的监护,患者死于多器官功能衰竭。由SP引起的感染可能会导致患者的高发病率,甚至导致上述患者因难以控制的系统性器官衰竭而死亡。充分的诊断,以及积极的医疗和手术管理可能不足以控制感染,即使是在以前没有免疫损害的患者。同时,一个多学科的方法必须是标准的治疗,旨在控制易感感染条件。这是国内文献报道的第一例与这两种致命疾病相关的病例。最后,本报告的目的之一是强调,尽管有报道称这种微生物感染了婴儿和免疫功能低下的患者,但在健康患者中不应排除这种微生物,特别是在感染迅速传播且对适当管理缺乏反应的情况下。证据等级:IV
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Poliartritis séptica y fascitis necrotizante en un paciente inmunocompetente. Reporte de caso

Septic polyarthritis in an immunocompetent patient is highly rare, even more when it coexists with necrotizing fasciitis caused by Streptococcus Pyogenes (SP). A 54 year old, immunocompetent male patient is presented herein. The patient had no relevant previous illness, before the installation of a septic arthritis of both knees and he's left ankle. He receives treatment with sequential surgical debridement, then develops necrotizing fasciitis of the posterior aspect of the left leg requiring adequate treatment for such condition (including Vacuum Assisted Closure), as well as antibiotic therapy for the specific infecting microorganism (Penicillin + Vancomycin). Nonetheless, after a month of surgical management between Plastic Surgery, Dermatology, Orthopaedics as well as surveillance in the Intensive Care Unit, the patient dies after multi organic failure. Infection caused by SP might entail high morbidity for a patient and even end with death of the aforementioned caused by a hard to manage systemic organic failure. The adequate diagnosis, as well as aggressive medical and surgical management could not be enough for controlling the infection, even in patients without previous immunological compromise. At the same time, a multidisciplinary approach must be the standard of treatment, aiming to control predisposing infectious conditions. This is the first case reported in national literature related to these two fatal conditions. Finally, one of the purposes of this report is to highlight that despite reports of this microorganism infecting infants and immunocompromised patients, it must not be obviated in healthy patients, especially in cases of rapidly spreading infection and scarce response to adequate management.

Evidence Level: IV

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