Mengmeng Liu, Chi Yu, Ying-feng Su, Shuai Li, Guoqian Yang
{"title":"载药壳聚糖/羟基磷灰石复合材料的制备及其在鼻腔缺损修复中的数值模拟","authors":"Mengmeng Liu, Chi Yu, Ying-feng Su, Shuai Li, Guoqian Yang","doi":"10.4015/s1016237223500163","DOIUrl":null,"url":null,"abstract":"With the continuous innovation and development of materials science and tissue engineering technology, biomaterials are gradually being used to replace autologous bone and allogeneic bone grafts in clinical practice for the treatment and repair of bone defects. In this paper, L-arginine-modified chitosan/hydroxyapatite composites were prepared by solution blending of L-arginine-modified chitosan and hydroxyapatite. A hormone drug prednisone acetate was loaded into the composites by supercritical impregnation technique. The results of in vitro release showed that under the loading condition of 12 MPa and 318 K, the cumulative release amount of the drug was 74.6% in 72 h, which had an excellent sustained release effect. In addition, a numerical model of the nasal bone was developed and numerical calculations were performed to analyze and compare the stresses of the healthy nasal bone and the nasal bone repaired with CA/HA composite when subjected to a force of 100 N, in different directions. The total deformation difference at the material was 0.002-0.004 mm/mm, and the stress difference was 0.004–1.373 MPa for the nasal bone in both states, with the sagittal plane under 0–90 degrees of force. The above results indicate that the CA/HA composite has good biological and mechanical properties and can be used to repair nasal bone defects. This material and numerical calculation method can also be applied to other related bone tissue engineering and biomedical materials, which have broad application prospects.","PeriodicalId":8862,"journal":{"name":"Biomedical Engineering: Applications, Basis and Communications","volume":"19 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PREPARATION OF DRUG-LOADED CHITOSAN/HYDROXYAPATITE COMPOSITE MATERIAL AND ITS NUMERICAL SIMULATION IN NASAL DEFECT REPAIR\",\"authors\":\"Mengmeng Liu, Chi Yu, Ying-feng Su, Shuai Li, Guoqian Yang\",\"doi\":\"10.4015/s1016237223500163\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"With the continuous innovation and development of materials science and tissue engineering technology, biomaterials are gradually being used to replace autologous bone and allogeneic bone grafts in clinical practice for the treatment and repair of bone defects. In this paper, L-arginine-modified chitosan/hydroxyapatite composites were prepared by solution blending of L-arginine-modified chitosan and hydroxyapatite. A hormone drug prednisone acetate was loaded into the composites by supercritical impregnation technique. The results of in vitro release showed that under the loading condition of 12 MPa and 318 K, the cumulative release amount of the drug was 74.6% in 72 h, which had an excellent sustained release effect. In addition, a numerical model of the nasal bone was developed and numerical calculations were performed to analyze and compare the stresses of the healthy nasal bone and the nasal bone repaired with CA/HA composite when subjected to a force of 100 N, in different directions. The total deformation difference at the material was 0.002-0.004 mm/mm, and the stress difference was 0.004–1.373 MPa for the nasal bone in both states, with the sagittal plane under 0–90 degrees of force. The above results indicate that the CA/HA composite has good biological and mechanical properties and can be used to repair nasal bone defects. This material and numerical calculation method can also be applied to other related bone tissue engineering and biomedical materials, which have broad application prospects.\",\"PeriodicalId\":8862,\"journal\":{\"name\":\"Biomedical Engineering: Applications, Basis and Communications\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Engineering: Applications, Basis and Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4015/s1016237223500163\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Engineering: Applications, Basis and Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4015/s1016237223500163","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
PREPARATION OF DRUG-LOADED CHITOSAN/HYDROXYAPATITE COMPOSITE MATERIAL AND ITS NUMERICAL SIMULATION IN NASAL DEFECT REPAIR
With the continuous innovation and development of materials science and tissue engineering technology, biomaterials are gradually being used to replace autologous bone and allogeneic bone grafts in clinical practice for the treatment and repair of bone defects. In this paper, L-arginine-modified chitosan/hydroxyapatite composites were prepared by solution blending of L-arginine-modified chitosan and hydroxyapatite. A hormone drug prednisone acetate was loaded into the composites by supercritical impregnation technique. The results of in vitro release showed that under the loading condition of 12 MPa and 318 K, the cumulative release amount of the drug was 74.6% in 72 h, which had an excellent sustained release effect. In addition, a numerical model of the nasal bone was developed and numerical calculations were performed to analyze and compare the stresses of the healthy nasal bone and the nasal bone repaired with CA/HA composite when subjected to a force of 100 N, in different directions. The total deformation difference at the material was 0.002-0.004 mm/mm, and the stress difference was 0.004–1.373 MPa for the nasal bone in both states, with the sagittal plane under 0–90 degrees of force. The above results indicate that the CA/HA composite has good biological and mechanical properties and can be used to repair nasal bone defects. This material and numerical calculation method can also be applied to other related bone tissue engineering and biomedical materials, which have broad application prospects.
期刊介绍:
Biomedical Engineering: Applications, Basis and Communications is an international, interdisciplinary journal aiming at publishing up-to-date contributions on original clinical and basic research in the biomedical engineering. Research of biomedical engineering has grown tremendously in the past few decades. Meanwhile, several outstanding journals in the field have emerged, with different emphases and objectives. We hope this journal will serve as a new forum for both scientists and clinicians to share their ideas and the results of their studies.
Biomedical Engineering: Applications, Basis and Communications explores all facets of biomedical engineering, with emphasis on both the clinical and scientific aspects of the study. It covers the fields of bioelectronics, biomaterials, biomechanics, bioinformatics, nano-biological sciences and clinical engineering. The journal fulfils this aim by publishing regular research / clinical articles, short communications, technical notes and review papers. Papers from both basic research and clinical investigations will be considered.