载药壳聚糖/羟基磷灰石复合材料的制备及其在鼻腔缺损修复中的数值模拟

Mengmeng Liu, Chi Yu, Ying-feng Su, Shuai Li, Guoqian Yang
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引用次数: 0

摘要

随着材料科学和组织工程技术的不断创新和发展,生物材料在临床实践中逐渐被用于替代自体骨和异体骨移植物,用于骨缺损的治疗和修复。本文采用l -精氨酸修饰壳聚糖与羟基磷灰石溶液共混的方法制备了l -精氨酸修饰壳聚糖/羟基磷灰石复合材料。采用超临界浸渍技术将激素类药物醋酸强的松装入复合材料。体外释放结果显示,在12 MPa、318 K的加载条件下,72 h内药物的累积释放量为74.6%,具有优异的缓释效果。此外,建立了鼻骨的数值模型,并进行数值计算,分析比较了健康鼻骨和CA/HA复合材料修复的鼻骨在不同方向上受100 N力时的应力变化。在0 ~ 90度受力情况下,两种状态下鼻骨矢状面总变形差为0.002 ~ 0.004 mm/mm,应力差为0.004 ~ 1.373 MPa。上述结果表明,CA/HA复合材料具有良好的生物力学性能,可用于修复鼻骨缺损。该材料及其数值计算方法也可应用于其他相关的骨组织工程和生物医用材料,具有广阔的应用前景。
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PREPARATION OF DRUG-LOADED CHITOSAN/HYDROXYAPATITE COMPOSITE MATERIAL AND ITS NUMERICAL SIMULATION IN NASAL DEFECT REPAIR
With the continuous innovation and development of materials science and tissue engineering technology, biomaterials are gradually being used to replace autologous bone and allogeneic bone grafts in clinical practice for the treatment and repair of bone defects. In this paper, L-arginine-modified chitosan/hydroxyapatite composites were prepared by solution blending of L-arginine-modified chitosan and hydroxyapatite. A hormone drug prednisone acetate was loaded into the composites by supercritical impregnation technique. The results of in vitro release showed that under the loading condition of 12 MPa and 318 K, the cumulative release amount of the drug was 74.6% in 72 h, which had an excellent sustained release effect. In addition, a numerical model of the nasal bone was developed and numerical calculations were performed to analyze and compare the stresses of the healthy nasal bone and the nasal bone repaired with CA/HA composite when subjected to a force of 100 N, in different directions. The total deformation difference at the material was 0.002-0.004 mm/mm, and the stress difference was 0.004–1.373 MPa for the nasal bone in both states, with the sagittal plane under 0–90 degrees of force. The above results indicate that the CA/HA composite has good biological and mechanical properties and can be used to repair nasal bone defects. This material and numerical calculation method can also be applied to other related bone tissue engineering and biomedical materials, which have broad application prospects.
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来源期刊
Biomedical Engineering: Applications, Basis and Communications
Biomedical Engineering: Applications, Basis and Communications Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.50
自引率
11.10%
发文量
36
审稿时长
4 months
期刊介绍: Biomedical Engineering: Applications, Basis and Communications is an international, interdisciplinary journal aiming at publishing up-to-date contributions on original clinical and basic research in the biomedical engineering. Research of biomedical engineering has grown tremendously in the past few decades. Meanwhile, several outstanding journals in the field have emerged, with different emphases and objectives. We hope this journal will serve as a new forum for both scientists and clinicians to share their ideas and the results of their studies. Biomedical Engineering: Applications, Basis and Communications explores all facets of biomedical engineering, with emphasis on both the clinical and scientific aspects of the study. It covers the fields of bioelectronics, biomaterials, biomechanics, bioinformatics, nano-biological sciences and clinical engineering. The journal fulfils this aim by publishing regular research / clinical articles, short communications, technical notes and review papers. Papers from both basic research and clinical investigations will be considered.
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