紫金桃科紫金桃叶的化学特性、毒性及抗菌活性研究

J. H. Faleiro, R. C. Gonçalves, Mara Núbia Guimarães dos Santos, Diego Pereira da Silva, P. Naves, G. Malafaia
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引用次数: 14

摘要

据了解,作为桃金娘科植物,其组成物种Psidium cattleanum的植物化学鉴定和生物效应评价文献很少。本研究的目的是研究牛皮草叶片次生代谢产物的组成、毒性和抗菌活性。通过浸渍和正己烷、二氯甲烷、乙酸乙酯分馏得到该植物粗乙醇提取物。对粗乙醇提取物和馏分进行了植物化学筛选,并对微甲壳类动物盐渍蒿进行了毒理学评价。采用琼脂扩散法对金黄色葡萄球菌、表皮葡萄球菌、洋葱伯克氏菌和大肠杆菌进行抑菌试验。检测到多种次生代谢物,如儿茶素、类固醇、酚类化合物、黄酮类化合物和皂苷。在毒性方面,己烷和二氯甲烷组分被认为是无毒的,而粗乙醇提取物和乙酸乙酯组分则是低毒的。除己烷部分外,乙醇粗提物及其各馏分对被试菌均有活性。因此,其次级代谢产物的组成、低毒性和抗菌活性表明该物种在寻找和开发新药方面具有广阔的前景。
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The Chemical Featuring, Toxicity, and Antimicrobial Activity of Psidium cattleianum (Myrtaceae) Leaves
It is known that the phytochemical identification and assessment of biological effects caused by the constituent species Psidium cattleianum, which belongs to family Myrtaceae, are poorly held in the literature. The aim of the current study is to investigate the composition of secondary metabolites, the toxicity, and the antimicrobial activity of P. cattleianum leaves. The crude ethanolic extract of the plant was obtained through maceration and fractionated with hexane, dichloromethane, and ethyl acetate. The crude ethanol extract and the fractions were subjected to phytochemical screening and tested against the microcrustacean Artemia salina for toxicological assessment. Antimicrobial tests with crude ethanol extract and the fractions were carried out through the agar diffusion method using broth microdilution against Staphylococcus aureus, S. epidermidis, Burkholderia cepacia, and Escherichia coli strains. A variety of secondary metabolite groups such as catechins, steroids, phenolic compounds, flavonoids, and saponins was detected. Regarding toxicity, hexane and dichloromethane fractions were considered nontoxic, whereas the crude ethanol extract and the ethyl acetate fraction showed low toxicity. The crude ethanol extract and the fractions, except for the hexane fraction, showed activity against the tested strains. Therefore, the composition of the secondary metabolites, the low toxicity, and the antimicrobial activity suggest that this species is promising in the search and development of new drugs.
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