Blocking OMARS designs and definitive screening designs

Abstract The family of orthogonal minimally aliased response surface or OMARS designs comprises traditional response surface designs, such as central composite designs and Box-Behnken designs, as well as definitive screening designs. Key features of OMARS designs are the facts that they are orthogonal for the main effects and that the main effects are not at all aliased with any two-factor interaction effect or with any quadratic effect. In this article, we present a method to arrange the runs of an OMARS design in blocks of equal size, so that the main effects can be estimated independently from the blocks, and the interaction effects and the quadratic effects are confounded as little as possible with the blocks. We show that our new method for blocking OMARS designs offers much flexibility when it comes to choosing the number of runs, the number of blocks and the block sizes, and that it often outperforms the blocking arrangements of definitive screening designs available in the literature and in commercial software.