生物制剂时代用JK膜置换术治疗肘关节:附2例报告

C. Weijia, R. Nagamine
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Then, the fascia was exposed to direct sunlight in order to reduce the dichromic acid. The fascia was washed out in running water for 24 hours and was then stored in phenol with the addition of 70% alcohol. Elbow arthroplasties were performed on three elbow joints in two young female patients. The first case had a significantly damaged right elbow joint with severe joint dysfunction. A JK membrane arthroplasty was done for the first case in 2003, when this patient was 34 years old. Biologics were administered with methotrexate after the surgery. The second case demonstrated bilateral ankylosed elbows due to idiopathic juvenile arthritis. Bilateral JK membrane arthroplasties were performed in 2010, when this patient was 32 years old. Several operative and manual manipulations were necessary in order to increase the range of motion following surgery. Biologics were administered with cyclosporine. Results: Joint function was significantly improved in all three joints without pain after the JK membrane elbow arthroplasties. In case one, the JOA (Japan Orthopaedic Association) elbow score improved from 21 points before surgery to 85 points after surgery and active elbow flexion improved to 110 degrees following surgery. In case two, the JOA elbow score was 55 and 82 points in the right elbow and 52 and 83 points in left elbow before and after surgery, respectively. In case two, active flexion improved to 120 degrees for the right elbow and 110 degrees for the left elbow following surgery. RA was well controlled in both patients. 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摘要

目的:全肘关节置换术的寿命有限,因此不适合年轻的类风湿关节炎患者。使用位置间膜的关节成形术可能是该人群的另一种手术选择。然而,使用位置间膜进行关节置换术的临床结果传统上并不理想,因为类风湿活动无法控制。今天,类风湿活动可以用生物制剂控制;因此,重新评估了位置间膜手术的效用。方法:从患者的阔筋膜张肌上剥离8×6 cm的筋膜,制成JK膜。筋膜在支架上拉伸,在2%铬酸钾溶液中保存24小时。然后,将筋膜暴露在阳光直射下,以减少重铬酸。将筋膜在自来水中冲洗24小时,然后在苯酚中添加70%的酒精保存。对2例年轻女性患者的3个肘关节进行了肘关节置换术。第一例患者右肘关节明显受损,伴有严重的关节功能障碍。第一例患者于2003年进行了JK膜关节置换术,当时患者34岁。术后给予生物制剂和甲氨蝶呤。第二个病例显示双侧强直肘部由于特发性幼年关节炎。于2010年行双侧JK膜置换手术,患者32岁。为了增加手术后的活动范围,一些手术和手动操作是必要的。生物制剂与环孢素一起使用。结果:JK膜肘关节置换术后关节功能明显改善,无疼痛。病例一,JOA(日本骨科协会)肘关节评分从术前的21分提高到术后的85分,术后肘关节活动度提高到110度。病例二,手术前后右肘JOA评分分别为55分和82分,左肘JOA评分分别为52分和83分。病例二,手术后右肘主动屈曲度提高到120度,左肘主动屈曲度提高到110度。两例患者RA均得到良好控制。结论:在使用生物制剂控制RA活动的年轻患者中,使用位置间膜的肘关节置换术似乎是有用的。
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Elbow Arthroplasty Using Inter-Positional JK Membrane in the Era of Biologics: A Report of Two Cases
Objective: Total elbow joint arthroplasty has limited longevity and is therefore not appropriate for younger rheumatoid arthritis patients. Arthroplasty using an inter-positional membrane may be another surgical option for this population. However, clinical results for joint arthroplasty using the inter-positional membrane have not traditionally been favorable because rheumatoid activity could not be controlled. Today, rheumatoid activity can be controlled with biologics; therefore, the utility of the inter-positional membrane procedure was re-evaluated. Methods: An 8×6 cm sheet of fascia was detached from the patient9s tensor fascia lata muscle to produce a JK membrane. The fascia was stretched on a frame and kept in a 2% chromic acid potassium solution for 24 hours. Then, the fascia was exposed to direct sunlight in order to reduce the dichromic acid. The fascia was washed out in running water for 24 hours and was then stored in phenol with the addition of 70% alcohol. Elbow arthroplasties were performed on three elbow joints in two young female patients. The first case had a significantly damaged right elbow joint with severe joint dysfunction. A JK membrane arthroplasty was done for the first case in 2003, when this patient was 34 years old. Biologics were administered with methotrexate after the surgery. The second case demonstrated bilateral ankylosed elbows due to idiopathic juvenile arthritis. Bilateral JK membrane arthroplasties were performed in 2010, when this patient was 32 years old. Several operative and manual manipulations were necessary in order to increase the range of motion following surgery. Biologics were administered with cyclosporine. Results: Joint function was significantly improved in all three joints without pain after the JK membrane elbow arthroplasties. In case one, the JOA (Japan Orthopaedic Association) elbow score improved from 21 points before surgery to 85 points after surgery and active elbow flexion improved to 110 degrees following surgery. In case two, the JOA elbow score was 55 and 82 points in the right elbow and 52 and 83 points in left elbow before and after surgery, respectively. In case two, active flexion improved to 120 degrees for the right elbow and 110 degrees for the left elbow following surgery. RA was well controlled in both patients. Conclusion: Elbow arthroplasty using an inter-positional membrane appears to be useful in young patients when RA activity is controlled with biologics.
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