新型zn (ii) -l-cu (ii)配合物与重要生物分子的取代反应及抗菌活性研究

Biljana M Šmit, Asija Halilagić, Enisa Selimović, Jelena Katanić Stanković, N. Srećković, T. Soldatović
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引用次数: 0

摘要

合成了具有不同桥接配体的新型双核Zn(II)-L-Cu(II)配合物。用紫外可见分光光度法研究了这些配合物与生物学上重要的亲核试剂5′-GMP、5′-IMP和GSH的相互作用。金属离子之间的距离导致两个中心的反应性降低,因为它们之间的电子通信减少了,金属中心本身的电子密度增加了。这两种配合物对大多数测试的细菌和真菌菌株都显示出中等的抗菌活性。
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STUDIES OF SUBSTITUTION REACTIONS WITH IMPORTANT BIOMOLECULES AND ANTIMICROBIAL ACTIVITY OF NOVEL ZN(II)-L-CU(II) COMPLEXES
New dinuclear Zn(II)-L-Cu(II) complexes with different bridging ligands were synthesized. Interactions of these complexes with biologically important nucleophiles, 5′-GMP, 5′-IMP and GSH, were investigated by Uv-Vis spectrofotometric method. The distances between the metal ions lead to less reactivity of both centers due to reduced electronic communication between them and an increasing of electron density on the metal centers itself. Both complexes showed moderate antimicrobial activity against most of the tested bacterial and fungal strains.
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