长期摄入脱氧雪腐镰刀菌醇污染的饮食剂量依赖性地减少了大鼠的肌肠神经元和胶质细胞的面积

Neurogastroenterology & Motility Pub Date : 2019-12-03 DOI:10.1111/nmo.13770

Débora Furlan Rissato, Ana Paula de Santi Rampazzo, S. Borges, F. C. Sousa, C. Busso, N. Buttow, M. Natali

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引用次数: 11

摘要

脱氧雪腐镰刀菌醇(DON)是一种由镰刀菌产生的霉菌毒素，通常存在于人类和动物摄入的谷物中。其摄入与肝脏、血液学、肾脏、脾、心脏、胃肠和神经损伤有关，根据剂量、暴露时间和种类而定。在这项研究中，研究人员评估了人类和动物摄入可耐受浓度的DON污染饮食的影响。

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Chronic ingestion of deoxynivalenol‐contaminated diet dose‐dependently decreases the area of myenteric neurons and gliocytes of rats

Deoxynivalenol (DON), a mycotoxin produced by Fusarium spp., is commonly found in cereals ingested by humans and animals. Its ingestion is correlated with hepatic, hematologic, renal, splenic, cardiac, gastrointestinal, and neural damages, according to dose, duration of exposure and species. In this work, the effects of the ingestion of DON‐contaminated diet at concentrations considered tolerable for human and animal intake were assessed.

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Neurogastroenterology & Motility

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