{"title":"蛋白限制是否有利于T淋巴细胞通过Myc激活对抗病原体?","authors":"Jung-eun Lee","doi":"10.15406/MOJI.2018.06.00213","DOIUrl":null,"url":null,"abstract":"One area that presents a significant threat to global health is infectious diseases. With increasing prevalence of antibiotic-resistant bacteria [1], opportunistic infections are a growing concern for human societies. In 2009, there were 89,000 deaths caused by pneumonia, septicemia, and influenza virus in the United States alone [2]. Antibiotic-resistant bacteria increase the risk of secondary infection that is associated with many standard medical procedures such as organ transplantation, chemotherapy, dialysis, and elective surgery [1]. The deceleration of new drug discovery suggests that acute preventative strategies strengthening host immunity prior to such procedures are of strong interest. In this mini review, I will suggest a protein restriction-Myc signaling as a potential pharmacological target to boost the survival outcome following pathogenic bacterial infection.","PeriodicalId":92105,"journal":{"name":"MOJ lymphology & phlebology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Can Protein Restriction Set Up T Lymphocytes Favorably For Their Activation Against Pathogens Through Myc?\",\"authors\":\"Jung-eun Lee\",\"doi\":\"10.15406/MOJI.2018.06.00213\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"One area that presents a significant threat to global health is infectious diseases. With increasing prevalence of antibiotic-resistant bacteria [1], opportunistic infections are a growing concern for human societies. In 2009, there were 89,000 deaths caused by pneumonia, septicemia, and influenza virus in the United States alone [2]. Antibiotic-resistant bacteria increase the risk of secondary infection that is associated with many standard medical procedures such as organ transplantation, chemotherapy, dialysis, and elective surgery [1]. The deceleration of new drug discovery suggests that acute preventative strategies strengthening host immunity prior to such procedures are of strong interest. In this mini review, I will suggest a protein restriction-Myc signaling as a potential pharmacological target to boost the survival outcome following pathogenic bacterial infection.\",\"PeriodicalId\":92105,\"journal\":{\"name\":\"MOJ lymphology & phlebology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"MOJ lymphology & phlebology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/MOJI.2018.06.00213\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"MOJ lymphology & phlebology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/MOJI.2018.06.00213","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Can Protein Restriction Set Up T Lymphocytes Favorably For Their Activation Against Pathogens Through Myc?
One area that presents a significant threat to global health is infectious diseases. With increasing prevalence of antibiotic-resistant bacteria [1], opportunistic infections are a growing concern for human societies. In 2009, there were 89,000 deaths caused by pneumonia, septicemia, and influenza virus in the United States alone [2]. Antibiotic-resistant bacteria increase the risk of secondary infection that is associated with many standard medical procedures such as organ transplantation, chemotherapy, dialysis, and elective surgery [1]. The deceleration of new drug discovery suggests that acute preventative strategies strengthening host immunity prior to such procedures are of strong interest. In this mini review, I will suggest a protein restriction-Myc signaling as a potential pharmacological target to boost the survival outcome following pathogenic bacterial infection.