百里香、绿薄荷和丁香油提取物制备乳化液喷雾剂治疗动物口腔溃疡和牛口蹄疫的研究

Zainab Farooq, Feryal Majed, Ahmed Jibeer, Arej Ali, Rahim Jabbar
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引用次数: 0

摘要

口腔溃疡在动物中很常见,原因有很多,包括在食用饲料或食物过程中发生的意外伤害,也可能是细菌、真菌或病毒引起的,比如口蹄疫,口蹄疫通常伴有口腔、乳房和足部溃疡(FMD),导致动物禁食,然后死亡。为了找到解决这个问题的方法,人们从薄荷提取物中提取了一种药物配方,百里香和丁香叫它(薄荷兽医)。油通过水蒸发提取,然后通过气相色谱-质谱联用检测,并参加了许多配方,直到达到完美的稠度和稳定性,其中药物形式是白色乳剂,以漱口水的形式保存在喷雾瓶中。在低温4℃和室温25℃两种温度下对该产品进行了为期6个月的生物稳定性试验,确定了有效期和最佳储存条件,并与标准庆大霉素和制霉菌素进行了比较,配方的抑菌区高于标准抑菌区,由于产品含有精油,避免了高温,计算了有效期2年,并在低于15℃的条件下储存。该配方已在Al-Rashedia和巴格达的兽医医院试用,报告证明了漱口水的有效性,并有显著的反应,当它用于治疗口蹄疫时,没有任何副作用。
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Preparation of a Medicinal Formula as Emulsion Spray from Oil Extracts of Thyme, Spearmint and Clove to Treat Oral Ulcers in Animals and FMD in Cattle
Oral ulcers are common occurrences in animals for many reasons, including accidental injuries that occur during the consumption of feed or food, and may be bacterial and fungal or viral causes such as foot-and-mouth disease, which is usually accompanied by ulcers in the mouth, udder and foot (FMD), which leads to the animal's abstinence from food and then death so to find ways that solve this problem a pharmaceutical formula had been prepared from extract oils mint, thyme and cloves called it (mint vet). The oils were extracted by water evaporation then examined by GC-MS and attended many formulations until reaching the until reaching the perfect consistency and stability where the pharmaceutical form was white emulsion kept inside a spray bottle given in the form of a mouthwash. The biological test stability was conducted on the product for six months at two temperatures one of them cold degree 4°C and the other is room temperature 25°C to determine the expiration   date and the best storage conditions, it has been compare with stander Gentamicin and Nystatin the inhibition zone of formula was higher than stander inhibition zone, high temperature was avoided because the product contains essential oil, the expiry date was calculated two years and store at less 15°C. The formula has been tasted in veterinary hospitals in Al-Rashedia and Baghdad, the report had proved the efficiency of the mouth wash and there are significant responses, when it’s used to treat Foot and Mouth Disease FMD without any side effect.
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