大豆多糖的治疗和技术方面

Q4 Pharmacology, Toxicology and Pharmaceutics Acta Marisiensis - Seria Medica Pub Date : 2021-12-01 DOI:10.2478/amma-2021-0040
R. Vlad, P. Antonoaea, E. Rédai, D. Muntean, N. Todoran, M. Bîrsan, A. Tataru, A. Ciurba
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引用次数: 1

摘要

大豆多糖是一种多用途的化学物质,包括治疗和技术性质。自从首次被引入制药领域以来,大豆多糖被用于两种不同的药物配方中;舌下片剂和结肠给药。对于舌下片剂,大豆多糖(品牌为Emcosoy©)被用作超崩解剂,浓度在4-8%之间,其结果与人工超崩解剂(乙醇酸淀粉钠、交果糖钠和聚乙烯吡咯烷酮)相当。使用大豆多糖的第二个技术领域是结肠给药,它与乙基纤维素结合使用,与文献中发现的结果相比,延迟时间更长。这些多糖的药用作用包括治疗腹泻。正如本文所述,这些化合物倾向于减少腹泻患者的含水便时间,并引导健康患者的大便变得更软。综上所述,这些多糖具有多种用途,具有药用作用,也有可能用作双重药用辅料。
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Soy polysaccharides therapeutic and technological aspects
Abstract Soy polysaccharides represent a multipurpose class of chemicals that include both therapeutical and technological properties. Since they have been first time introduced in the pharmaceutical field, Soy polysaccharides were used in two different pharmaceutical formulations; sublingual tablets and in colon drug delivery. For the sublingual tablets, Soy polysaccharides under the brand name of Emcosoy© - were used as a superdisintegrant in concentrations between 4-8% showing comparable results with the artificial superdisintegrants (sodium starch glycolate, sodium croscarmellose, and polyvinylpyrrolidone). The second technological field where Soy polysaccharides were used is represented by colon drug delivery where it was used in combination with ethylcellulose showing a prolonged lag time compared to the results found in the literature. The medicinal effect of these polysaccharides consists of treating diarrhea. As it will be presented in the article, these chemical compounds tend to decrease the aqueous stool time in patients with diarrhea and to conduct to a softer stool in healthy patients. In conclusion, these polysaccharides present multiple purposes possessing a medicinal effect and also the possibility of being used as a double-faceted pharmaceutical excipient.
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来源期刊
Acta Marisiensis - Seria Medica
Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.40
自引率
0.00%
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0
审稿时长
24 weeks
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