用机器学习分解临床差异

N. Hammarlund
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摘要

在获得高质量医疗服务的平均比率、特定疾病的死亡率以及紧急心脏护理等情况的手术方面的差异,表明了医疗保健领域的种族差异。缓解特定差距的最佳方法取决于主要驱动因素是健康风险差异还是医疗保健系统内的待遇差异。在本文中,我提出了对瓦哈卡-布林德分解框架的扩展,该框架利用临床数据和机器学习预测的进展来量化由于不同的临床健康和不同的医疗保健治疗而导致的给定差异的部分。该方法应用于印第安纳州一家主要学术医院系统的电子医疗记录数据,用于心脏病发作的手术决策,与标准方法得出的结论相比,该方法表明潜在的医疗保健治疗差异较小。该方法表明,1/3的心脏手术率差异可以用黑人和非黑人患者的临床健康变量差异来解释,这表明临床上记录为黑人的患者存在更差的相对社会健康风险。社会建构的种族概念所带来的不同健康风险表明,需要全社会范围的解决方案,以解决诸如获得医疗保健和社会经济地位等风险因素方面的差异。然而,即使在基于机器学习的临床健康调整之后,仍然存在巨大的心脏手术差距,占比率差异的2/3,这表明需要针对差异临床治疗的解决方案。
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Decomposition of Clinical Disparities with Machine Learning
Differences in average rates of access to quality care, mortality from specific diseases, and surgery for conditions such as emergency cardiac care point to racial disparities in healthcare. The optimal approach to alleviate a given disparity depends on whether the main driver is differential health risk or differential treatment within the healthcare system. In this paper, I propose an extension of the Oaxaca-Blinder decomposition framework that capitalizes on advances in clinical data and machine learning prediction to quantify the portions of a given disparity due to differential clinical health and differential healthcare treatment. The proposed method applied to the surgery decision for heart attacks using electronic medical records data from a major academic hospital system in Indiana suggests a smaller potential healthcare treatment disparity compared to the conclusion from the standard approach. The method reveals that 1/3 of the cardiac surgery rate difference can be explained by differences in clinical health variables between Black and non-Black patients pointing towards the existence of worse relative social health risks for patients clinically recorded as Black. Differential health risks for the socially constructed concept of race indicates the need for society-wide solutions to address differences in risk factors such as healthcare access and socioeconomic status. However, a substantial cardiac surgery disparity, constituting 2/3 of the rate difference, remains even after machine learning-based clinical health adjustment pointing towards the need for solutions that target differential clinical treatment.
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