药用花卉对多重耐药大肠杆菌的抑菌活性研究

Iqra Nazir
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引用次数: 3

摘要

抗生素耐药性对疾病的治疗,特别是对耐多药大肠杆菌的治疗,构成了严峻的挑战。本研究通过现场试验和最低抑制浓度(MIC)试验,评价了七种不同花乙醇提取物对MDR大肠杆菌的抑菌活性,分别为千叶阿基雅(Achillea milleium)、木棉(Bombax ceiba)、金菊(Chrysanthemum cinerarifolium)、牛膝草(Hyssopus officinalis)、玫瑰(Rosa damascena Miller)、蒲公英(Taraxacum officinale Weber)和木足草(Woodfordia fruticosa)。结果表明,7种提取物对耐多药大肠杆菌及对照均有显著的抑菌活性。对耐多药大肠杆菌的MIC分别为3.125 mg/ml和12.5 mg/ml。千叶水蛭、牛膝草、金菊的MIC值分别为25 mg/ml和12.5 mg/ml。目前的研究表明,这些花具有较强的抗菌活性,可以作为潜在的抗多种耐药细菌病原体的抗菌剂
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Antibacterial Activity of Medicinal Flowers against Multi Drug Resistant E. coli
The antibiotic resistance is creating a serious challenge to treat diseases especially against multidrug resistant (MDR) E. coli. The present study was conducted to evaluate the antibacterial activity of seven different flowers ethanolic extracts named as Achillea millefolium, Bombax ceiba, Chrysanthemum cinerarifolium, Hyssopus officinalis, Rosa damascena Miller, Taraxacum officinale Weber and Woodfordia fruticosa against MDR E. coli through spot test and minimum inhibitory concentrations (MIC) test. The results showed all the seven extracts have significant antibacterial activity against MDR E. coli and control. The MIC of Rosa damascena Miller, Bombax ceiba was 3.125 mg/ml and Taraxacum officinale Weber was 12.5 mg/ml for MDR E. coli. Similarly, Achillea millefolium, Hyssopus officinalis, Chrysanthemum cinerarifolium MIC value was 25 mg/ml and 12.5 mg/ml for Woodfordia fruticosa Kurtz. The current study reveals that these flowers possess strong antibacterial activity and thus can be used as potential antimicrobial agent against various resistant bacterial pathogens
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