Mohamed A Gad, M. Bakry, Eman A Shehata, Noha A. Dabour
{"title":"杀虫硫脲:新型硫苯甲酰胺衍生物的制备及其对棉花叶虫生态友好型杀虫的生化影响","authors":"Mohamed A Gad, M. Bakry, Eman A Shehata, Noha A. Dabour","doi":"10.5267/j.ccl.2023.5.006","DOIUrl":null,"url":null,"abstract":"The following work could bring new insights into the application of heterocyclic N, N′-substituted thiobenzamide derivatives as novel pesticides. Insect growth regulators such as chitin synthesis inhibitors seem promising because of their specific mode of action on insects and their lower toxicity against vertebrates than conventional insecticides. Thus, a novel series of thiobenzamide derivatives have been prepared in a pure state. The structure of these synthesized compounds which related to the most famous insect growth regulator insecticides, were confirmed by elemental and modern spectroscopic analyses (IR, UV, 1HNMR and 13CNMR). Toxicological and biochemical parameters of the synthesized compounds against the cotton leafworm, Spodoptera littoralis under laboratory conditions were also investigated. Regarding the determined LC50 value for compound 2,4-Dichloro-N-[(2-methoxyphenyl)carbamothioyl]- benzamide 14 showed the most potent toxic effects than the other synthetic target compounds, with LC50 46.84 ppm of 2nd instar larvae and LC50 148.05of the 4th instar larvae.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"25 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Insecticidal thioureas: Preparation and biochemical impacts of some novel thiobenzamide derivatives as potential eco-friendly insecticidal against the cotton leafworm, Spodoptera littoralis (Boisd.)\",\"authors\":\"Mohamed A Gad, M. Bakry, Eman A Shehata, Noha A. Dabour\",\"doi\":\"10.5267/j.ccl.2023.5.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The following work could bring new insights into the application of heterocyclic N, N′-substituted thiobenzamide derivatives as novel pesticides. Insect growth regulators such as chitin synthesis inhibitors seem promising because of their specific mode of action on insects and their lower toxicity against vertebrates than conventional insecticides. Thus, a novel series of thiobenzamide derivatives have been prepared in a pure state. The structure of these synthesized compounds which related to the most famous insect growth regulator insecticides, were confirmed by elemental and modern spectroscopic analyses (IR, UV, 1HNMR and 13CNMR). Toxicological and biochemical parameters of the synthesized compounds against the cotton leafworm, Spodoptera littoralis under laboratory conditions were also investigated. Regarding the determined LC50 value for compound 2,4-Dichloro-N-[(2-methoxyphenyl)carbamothioyl]- benzamide 14 showed the most potent toxic effects than the other synthetic target compounds, with LC50 46.84 ppm of 2nd instar larvae and LC50 148.05of the 4th instar larvae.\",\"PeriodicalId\":10942,\"journal\":{\"name\":\"Current Chemistry Letters\",\"volume\":\"25 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Chemistry Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5267/j.ccl.2023.5.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Chemistry Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5267/j.ccl.2023.5.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 2
摘要
本研究为杂环N, N′取代噻吩酰胺衍生物作为新型农药的应用提供了新的思路。几丁质合成抑制剂等昆虫生长调节剂因其对昆虫的特殊作用方式和对脊椎动物的毒性较传统杀虫剂低而前景广阔。因此,以纯态制备了一系列新的硫苯甲酰胺衍生物。这些合成化合物的结构与最著名的昆虫生长调节剂杀虫剂有关,并通过元素和现代光谱分析(IR, UV, 1HNMR和13CNMR)进行了证实。并对合成的化合物在实验室条件下对棉花叶虫、沿海夜蛾的毒理学和生化指标进行了研究。化合物2,4-二氯- n -[(2-甲氧基苯基)氨基甲氧基]-苯甲酰胺14的LC50测定值为2龄幼虫的LC50为46.84 ppm,4龄幼虫的LC50为148.05 ppm,毒性作用最强。
Insecticidal thioureas: Preparation and biochemical impacts of some novel thiobenzamide derivatives as potential eco-friendly insecticidal against the cotton leafworm, Spodoptera littoralis (Boisd.)
The following work could bring new insights into the application of heterocyclic N, N′-substituted thiobenzamide derivatives as novel pesticides. Insect growth regulators such as chitin synthesis inhibitors seem promising because of their specific mode of action on insects and their lower toxicity against vertebrates than conventional insecticides. Thus, a novel series of thiobenzamide derivatives have been prepared in a pure state. The structure of these synthesized compounds which related to the most famous insect growth regulator insecticides, were confirmed by elemental and modern spectroscopic analyses (IR, UV, 1HNMR and 13CNMR). Toxicological and biochemical parameters of the synthesized compounds against the cotton leafworm, Spodoptera littoralis under laboratory conditions were also investigated. Regarding the determined LC50 value for compound 2,4-Dichloro-N-[(2-methoxyphenyl)carbamothioyl]- benzamide 14 showed the most potent toxic effects than the other synthetic target compounds, with LC50 46.84 ppm of 2nd instar larvae and LC50 148.05of the 4th instar larvae.
期刊介绍:
The "Current Chemistry Letters" is a peer-reviewed international journal which aims to publish all the current and outstanding research articles, reviews and letters in chemistry including analytical chemistry, green chemistry, inorganic chemistry, organic chemistry, physical chemistry, etc. This journal is dedicated to serve all academic and industrial researchers and scientists who are expert in all major advances in chemistry research. The journal aims to provide the most complete and reliable source of information on current developments in these fields. The emphasis will be on publishing quality articles rapidly and openly available to researchers worldwide. Please note readers are free to read, download, copy, distribute, print, search, or link to the full texts of articles published on this journal. Current Chemistry Letters is an open access journal, which provides instant access to the full text of research papers without any need for a subscription to the journal where the papers are published. Therefore, anyone has the opportunity to copy, use, redistribute, transmit/display the work publicly and to distribute derivative works, in any sort of digital form for any responsible purpose, subject to appropriate attribution of authorship. Authors who publish their articles may also maintain the copyright of their articles.