基于聚降冰片烯的神经接口微电极阵列

A. Hess, J. Dunning, D. Tyler, C. Zorman
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引用次数: 5

摘要

本文报道了一种以聚降冰片烯(PNB)为结构材料的机械柔性微加工平面神经电极的研制。该器件由两个电极阵列组成,每个电极阵列都在光刻定义的PNB基底上制造,具有薄膜Pt电极和光刻图案化的PNB覆盖层。这两个阵列被插入一个硅胶外壳中,在电极和神经束之间形成一个平坦的界面。电学测试表明,Pt电极互连走线的电阻不受1.8 mm半径弯曲的影响。在磷酸盐缓冲盐水(PBS)中进行电学测试表明,导线的电阻约为3komega。在PBS中进行10天的漏电流测试,漏电流没有产生可检测的变化。这些和其他测试表明,PNB多层体系可能是可行的微制造电极。
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A Polynorbornene-Based Microelectrode Array for Neural Interfacing
This paper reports the development of a mechanically-flexible microfabricated flat interface nerve electrode using polynorbornene (PNB) as the structural material. The device consists of two electrode arrays each fabricated on a photolithographically-defined PNB base with thin film Pt electrodes and a photolithographically patterned PNB capping layer. The two arrays are inserted into a silicone housing designed to create a flat interface between the electrodes and the nerve bundle. Electrical tests showed that the resistance of the Pt electrode interconnect traces are unaffected by flexing around a 1.8 mm radius. Electrical testing in phosphate-buffered saline (PBS) shows that resistance of the traces is about 3 kOmega. A 10 day leakage current test in PBS did not produce a detectable change in leakage current. These and other tests indicate that a PNB multilayer system may be viable for microfabricated electrodes.
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