细胞表面再循环受体的周期数

D. Steverding
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引用次数: 0

摘要

循环数(nc)的循环数被定义为受体在降解之前可以进行的往返(细胞表面-内体-细胞表面)的平均次数。回收受体的这个特征参数可以很容易地从受体的半衰期(t½,受体50%被降解的时间)和循环时间(Tc,受体完成一次往返所需的时间)确定。关系分析表明,nc随t1 / 2的增加呈线性增加,随Tc的增加呈指数下降。对于通常观察到的t1 / 2和Tc值,计算得出循环受体的nc值为100)。基于后一项发现,周期数nc可能是区分癌细胞和正常细胞的有用标准。
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Cycle Numbers of Cell Surface Recycling Receptors
The cycle number (nc) of a recycling receptor is defined as the average number of round trips (cell surface–endosome–cell surface) the receptor can make before it is degraded. This characteristic parameter of recycling receptors can be easily determined from the receptor’s half-life (t½, the time in which 50% of the receptor is degraded) and cycling time (Tc, the time a receptor needs to complete a round trip). Relationship analyses revealed that nc increases linearly with increasing t½ and decreases exponentially with increasing Tc. For commonly observed t½ and Tc values, it was calculated that recycling receptors have nc values of <300. In addition, it was found that recycling receptors in cancer cells have generally smaller nc values (<100), whereas recycling receptors in normal cells have larger nc values (>100). Based on this latter finding, the cycle number nc may be a useful criterion for distinguishing between cancer and normal cells.
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