SNPscan breeder -一个在育种程序中测试基因组工具的计算机程序

IF 1.1 4区 农林科学 Q3 FORESTRY Silvae Genetica Pub Date : 2023-01-01 DOI:10.2478/sg-2023-0013
B. Degen, Niels A. Müller
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引用次数: 0

摘要

SNPscan育种软件是一款能够模拟育种程序的软件,它使用模拟的个体全基因组数据、感兴趣性状的不同遗传结构、不同的交配设计和不同的选择标准,即表型、后代测试的育种值、标记辅助选择(MAS)和基因组选择(GS)。评价育种群体规模、交配设计、选择强度、遗传结构、遗传力和选择标准对遗传增益、亲缘关系、近交和遗传多样性的影响,优化育种方案。一个特殊的特点是,在全基因组关联研究(GWAS)的框架内,可以对不同的策略进行事后分析,以确定因果snp和等位基因效应。可以测量真阳性和假阳性snp的比例以及估计和真实等位基因效应的相关性,并且可以测试它们对育种计划成功的MAS使用的总体影响。
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SNPscan breeder – a computer program to test genomic tools in breeding programs
Abstract SNPscan breeder is a software that enables the simulation of breeding programs using simulated individual whole genome data, different genetic architectures of a trait of interest, different mating designs and different selection criteria, i.e. pheno-types, breeding values from progeny tests, marker-assisted selection (MAS) and genomic selection (GS). The impact of breeding population size, mating design, selection intensity, genetic architecture, heritability and selection criteria on genetic gains, kinship, inbreeding and genetic diversity can be evaluated to optimize the breeding program. A special feature is the possibility for post-hoc analysis of different strategies to identify causal SNPs and allele effects within the frame of genome-wide association studies (GWAS). The proportion of true and false positive SNPs and the correlation of estimated and true allelic effects can be measured and the overall impact of their use for MAS on the success of the breeding program can be tested.
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来源期刊
Silvae Genetica
Silvae Genetica 农林科学-林学
CiteScore
2.20
自引率
10.00%
发文量
10
审稿时长
3 months
期刊介绍: Silvae Genetica is an international peer reviewed journal with more than 65 year tradition and experience in all fields of theoretical and applied Forest Genetics and Tree breeding. It continues "Zeitschrift für Forstgenetik und Forstpflanzenzüchtung" (Journal of Forest Genetics and Forest Tree Breeding) founded by W. LANGNER in 1951.
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