镍(II)和铁(II)离子单基化4-氨基吡啶的合成与络合

IF 0.8 Q3 MULTIDISCIPLINARY SCIENCES Makara Journal of Science Pub Date : 2021-09-30 DOI:10.7454/mss.v25i3.1242
kingsley John Orie, R. Duru, R. Ngochindo
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引用次数: 3

摘要

甲酰基化4-氨基吡啶和其他磺化胺化合物构成了医学领域中用作抗生素的大量药物。本研究旨在合成甲酰基化4-氨基吡啶,并与Ni(II)和Fe(II)离子络合。在碱水介质中,氯甲酰与4-氨基吡啶反应制得磺胺。用Ni(NO3)2.6H2O /Fe(NO3)2.6H2O与磺胺衍生物反应合成配合物。通过紫外可见光谱(UV-Vis)、傅里叶变换红外光谱(FTIR)、质子核磁共振(1HNMR)、碳-13核磁共振(CNMR)、电子喷雾电离质谱仪(ESIMS)和微量分析对化合物进行了表征。红外光谱数据表明,磺胺衍生物作为Ni (II)和Fe (II)的中性配体,在它们的配合物中,1665.55和1674.21 cm−被分配给Ni−N和Fe−N键,1687.70 cm−被分配给游离甲基化4-氨基吡啶。自由亚胺到配位亚胺配合物的频带减小表明电子从配体转移到金属的d轨道。4-甲基- n-(吡啶-4-酰基)苯磺酰胺络合可以提高配体在制药和化学工业中的生物和催化潜力。
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Synthesis and Complexation of Monotosylated 4-Aminopyridine with Nickel (II) and Iron (II) Ions
Tosylated 4-aminopyridine and other sulfonylated compounds of amines comprise a substantial class of pharmaceutical drugs used as antibiotics in the field of medicine. This research aimed at the synthesis of tosylated 4-aminopyridine and the complexation of the tosyated 4-aminopyridine with Ni(II) and Fe(II) ions. The sulfonamide was prepared by the action of tosyl chloride on 4-aminopyridine in an aqueous alkaline medium. The complexes were synthesized by the reaction of Ni(NO3)2.6H2O /Fe(NO3)2.6H2O with sulfonamide derivative. These compounds were characterized through Ultraviolet Visible spectroscopy (UV–Vis), Fourier Transform Infer-Red (FTIR) spectroscopy, Proton Nuclear Magnetic Resonance (1HNMR), Carbon-13 Nuclear Magnetic Resonance (CNMR) and Electron Spray Ionisation-Mass Spectrometer (ESIMS) and micro-analysis. The IR spectral data suggested that the sulfonamide derivative acts as a neutral ligand towards Ni (II) and Fe (II). In their complexes, the coordination frequency bands of 1665.55 and 1674.21 cm− were assigned to Ni−N and Fe−N bonds, and 1687.70 cm− was assigned to free tosylated 4-aminopyridine. This decrease in the frequency band of free imine to coordinated imine complexes indicates that electron transfer occurred from the ligand to the d-orbitals of the metals. The complexation of4-Methyl-N-(pyridin-4-yl)benzene sulfonamide can increase the biological and catalytic potential of the ligand in the pharmaceutical and chemical industries.
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来源期刊
Makara Journal of Science
Makara Journal of Science MULTIDISCIPLINARY SCIENCES-
CiteScore
1.30
自引率
20.00%
发文量
24
审稿时长
24 weeks
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