ANO1/TMEM16A、Ca2+激活的Cl-通道在调节血压和血管重构中的功能

Zhiqiang Qu, Bingxiang Wang, Zhen Zhang, Li Ma, Dan C. Li, L. Zhuang, J. Chi, Jiaxiu Liu
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引用次数: 2

摘要

由于Ca2+活化的Cl-通道(CaCC)分子被鉴定为ANO1,近年来对其在血管功能中的作用的研究取得了重大进展。ANO1已被证实代表血管平滑肌细胞(VSMCs)中的CaCC通道。一般来说,ANO1在阻力大小的小动脉中表达较多。激活后,通过去极化控制VSMC膜电位。结果,电压依赖性Ca2+通道打开,导致Ca2+进入和VSMC收缩。因此,ANO1的功能对维持正常血压很重要。在激动剂(如血管紧张素II)的影响下,ANO1还参与由KLF5、心肌素和SRF介导的VSMC分化和重塑。这些因子调节ANO1基因和其他基因的转录,影响VSMC的分化和增殖。
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Functions of ANO1/TMEM16A, Ca2+-activated Cl- channels in Regulation of Blood Pressure and Vascular Remodeling
Since the molecule of Ca2+-activated Cl- channels (CaCC) had been identified as ANO1, major progresses have been made in recent studies on its roles in vascular functions. ANO1 has been confirmed to represent the CaCC channels in vascular smooth myocytes (VSMCs). Generally, ANO1 expresses more in resistance-size small arteries. When activated, it functions to control the VSMC membrane potentials by depolarization. As a result, the voltage-dependent Ca2+ channel is opened, leading to Ca2+ entry and VSMC contraction. Thus, the function of ANO1 is important for maintenance of normal blood pressure. Under influence of agonists, e.g., angiotensin II, ANO1 also participates in VSMC differentiation and remodeling which are mediated by KLF5, myocardin and SRF. The factors regulate the transcription of the ANO1 gene and other genes for VSMC differentiation and proliferation.
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